Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1802328..1802814 Replicon chromosome
Accession NZ_CP031634
Organism Streptococcus pyogenes strain MGAS11108

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZN89_RS09070 Protein ID WP_014407961.1
Coordinates 1802328..1802597 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZN89_RS09075 Protein ID WP_014407962.1
Coordinates 1802587..1802814 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZN89_RS09055 1797823..1798896 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZN89_RS09060 1799013..1801286 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZN89_RS09065 1801421..1801954 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZN89_RS09070 1802328..1802597 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZN89_RS09075 1802587..1802814 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZN89_RS09080 1802967..1803338 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZN89_RS09085 1803328..1803675 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZN89_RS09090 1803956..1804201 - 246 WP_011285304.1 hypothetical protein -
DZN89_RS09095 1804176..1804451 - 276 WP_014407964.1 hypothetical protein -
DZN89_RS09100 1804441..1804779 - 339 WP_030126557.1 replication protein -
DZN89_RS09105 1804821..1805087 - 267 WP_011285307.1 hypothetical protein -
DZN89_RS09110 1805084..1805872 - 789 WP_011285308.1 hypothetical protein -
DZN89_RS09475 1805963..1806121 - 159 WP_011285309.1 hypothetical protein -
DZN89_RS09115 1806135..1806380 - 246 WP_011285310.1 hypothetical protein -
DZN89_RS09120 1806376..1806702 - 327 Protein_1690 hypothetical protein -
DZN89_RS09480 1806704..1806877 - 174 WP_011285312.1 hypothetical protein -
DZN89_RS09125 1806883..1807056 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109586 WP_014407961.1 NZ_CP031634:c1802597-1802328 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109586 NZ_CP031634:c1802597-1802328 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109586 WP_014407962.1 NZ_CP031634:c1802814-1802587 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109586 NZ_CP031634:c1802814-1802587 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References