Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1829315..1829801 Replicon chromosome
Accession NZ_CP031632
Organism Streptococcus pyogenes strain MGAS28078

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZQ17_RS09215 Protein ID WP_014407961.1
Coordinates 1829315..1829584 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZQ17_RS09220 Protein ID WP_014407962.1
Coordinates 1829574..1829801 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZQ17_RS09200 1824810..1825883 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZQ17_RS09205 1826000..1828273 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZQ17_RS09210 1828408..1828941 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZQ17_RS09215 1829315..1829584 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZQ17_RS09220 1829574..1829801 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZQ17_RS09225 1829954..1830325 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZQ17_RS09230 1830315..1830662 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZQ17_RS09235 1830943..1831188 - 246 WP_011285304.1 hypothetical protein -
DZQ17_RS09240 1831163..1831438 - 276 WP_014407964.1 hypothetical protein -
DZQ17_RS09245 1831428..1831766 - 339 WP_030126557.1 replication protein -
DZQ17_RS09250 1831808..1832074 - 267 WP_011285307.1 hypothetical protein -
DZQ17_RS09255 1832071..1832859 - 789 WP_011285308.1 hypothetical protein -
DZQ17_RS09620 1832950..1833108 - 159 WP_011285309.1 hypothetical protein -
DZQ17_RS09260 1833122..1833367 - 246 WP_011285310.1 hypothetical protein -
DZQ17_RS09265 1833363..1833689 - 327 Protein_1719 hypothetical protein -
DZQ17_RS09625 1833691..1833864 - 174 WP_011285312.1 hypothetical protein -
DZQ17_RS09270 1833870..1834043 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109584 WP_014407961.1 NZ_CP031632:c1829584-1829315 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109584 NZ_CP031632:c1829584-1829315 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109584 WP_014407962.1 NZ_CP031632:c1829801-1829574 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109584 NZ_CP031632:c1829801-1829574 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References