Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1791365..1791851 Replicon chromosome
Accession NZ_CP031630
Organism Streptococcus pyogenes strain MGAS28271

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZR83_RS09010 Protein ID WP_014407961.1
Coordinates 1791365..1791634 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZR83_RS09015 Protein ID WP_014407962.1
Coordinates 1791624..1791851 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZR83_RS08995 1786860..1787933 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZR83_RS09000 1788050..1790323 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZR83_RS09005 1790458..1790991 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZR83_RS09010 1791365..1791634 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZR83_RS09015 1791624..1791851 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZR83_RS09020 1792004..1792375 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZR83_RS09025 1792365..1792712 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZR83_RS09030 1792993..1793238 - 246 WP_011285304.1 hypothetical protein -
DZR83_RS09035 1793213..1793488 - 276 WP_014407964.1 hypothetical protein -
DZR83_RS09040 1793478..1793816 - 339 WP_030126557.1 replication protein -
DZR83_RS09045 1793858..1794124 - 267 WP_011285307.1 hypothetical protein -
DZR83_RS09050 1794121..1794909 - 789 WP_011285308.1 hypothetical protein -
DZR83_RS09410 1795000..1795158 - 159 WP_011285309.1 hypothetical protein -
DZR83_RS09055 1795172..1795417 - 246 WP_011285310.1 hypothetical protein -
DZR83_RS09060 1795413..1795739 - 327 Protein_1674 hypothetical protein -
DZR83_RS09415 1795741..1795914 - 174 WP_011285312.1 hypothetical protein -
DZR83_RS09065 1795920..1796093 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109582 WP_014407961.1 NZ_CP031630:c1791634-1791365 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109582 NZ_CP031630:c1791634-1791365 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109582 WP_014407962.1 NZ_CP031630:c1791851-1791624 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109582 NZ_CP031630:c1791851-1791624 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References