Detailed information of TA system TA109582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1791365..1791851
• Replicon: chromosome
• Accession: NZ_CP031630
• Organism: Streptococcus pyogenes strain MGAS28271

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: DZR83_RS09010
• Protein ID: WP_014407961.1
• Coordinates: 1791365..1791634 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: DZR83_RS09015
• Protein ID: WP_014407962.1
• Coordinates: 1791624..1791851 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZR83_RS08995	1786860..1787933	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
DZR83_RS09000	1788050..1790323	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
DZR83_RS09005	1790458..1790991	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
DZR83_RS09010	1791365..1791634	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZR83_RS09015	1791624..1791851	-	228	WP_014407962.1	hypothetical protein	Antitoxin
DZR83_RS09020	1792004..1792375	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
DZR83_RS09025	1792365..1792712	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
DZR83_RS09030	1792993..1793238	-	246	WP_011285304.1	hypothetical protein	-
DZR83_RS09035	1793213..1793488	-	276	WP_014407964.1	hypothetical protein	-
DZR83_RS09040	1793478..1793816	-	339	WP_030126557.1	replication protein	-
DZR83_RS09045	1793858..1794124	-	267	WP_011285307.1	hypothetical protein	-
DZR83_RS09050	1794121..1794909	-	789	WP_011285308.1	hypothetical protein	-
DZR83_RS09410	1795000..1795158	-	159	WP_011285309.1	hypothetical protein	-
DZR83_RS09055	1795172..1795417	-	246	WP_011285310.1	hypothetical protein	-
DZR83_RS09060	1795413..1795739	-	327	Protein_1674	hypothetical protein	-
DZR83_RS09415	1795741..1795914	-	174	WP_011285312.1	hypothetical protein	-
DZR83_RS09065	1795920..1796093	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T109582 WP_014407961.1 NZ_CP031630:c1791634-1791365 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T109582 NZ_CP031630:c1791634-1791365 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT109582 WP_014407962.1 NZ_CP031630:c1791851-1791624 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT109582 NZ_CP031630:c1791851-1791624 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7