Detailed information of TA system TA109581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1841962..1842448
• Replicon: chromosome
• Accession: NZ_CP031629
• Organism: Streptococcus pyogenes strain MGAS28278

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: DZR90_RS09315
• Protein ID: WP_014407961.1
• Coordinates: 1841962..1842231 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: DZR90_RS09320
• Protein ID: WP_014407962.1
• Coordinates: 1842221..1842448 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZR90_RS09300	1837457..1838530	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
DZR90_RS09305	1838647..1840920	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
DZR90_RS09310	1841055..1841588	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
DZR90_RS09315	1841962..1842231	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZR90_RS09320	1842221..1842448	-	228	WP_014407962.1	hypothetical protein	Antitoxin
DZR90_RS09325	1842601..1842972	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
DZR90_RS09330	1842962..1843309	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
DZR90_RS09335	1843590..1843835	-	246	WP_011285304.1	hypothetical protein	-
DZR90_RS09340	1843810..1844085	-	276	WP_014407964.1	hypothetical protein	-
DZR90_RS09345	1844075..1844413	-	339	WP_030126557.1	replication protein	-
DZR90_RS09350	1844455..1844721	-	267	WP_011285307.1	hypothetical protein	-
DZR90_RS09355	1844718..1845506	-	789	WP_011285308.1	hypothetical protein	-
DZR90_RS09725	1845597..1845755	-	159	WP_011285309.1	hypothetical protein	-
DZR90_RS09360	1845769..1846014	-	246	WP_011285310.1	hypothetical protein	-
DZR90_RS09365	1846010..1846336	-	327	Protein_1744	hypothetical protein	-
DZR90_RS09730	1846338..1846511	-	174	WP_011285312.1	hypothetical protein	-
DZR90_RS09370	1846517..1846690	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T109581 WP_014407961.1 NZ_CP031629:c1842231-1841962 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T109581 NZ_CP031629:c1842231-1841962 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT109581 WP_014407962.1 NZ_CP031629:c1842448-1842221 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT109581 NZ_CP031629:c1842448-1842221 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7