Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1841571..1842057 Replicon chromosome
Accession NZ_CP031627
Organism Streptococcus pyogenes strain MGAS28360

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZS66_RS09320 Protein ID WP_014407961.1
Coordinates 1841571..1841840 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZS66_RS09325 Protein ID WP_014407962.1
Coordinates 1841830..1842057 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZS66_RS09305 1837066..1838139 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZS66_RS09310 1838256..1840529 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZS66_RS09315 1840664..1841197 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZS66_RS09320 1841571..1841840 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZS66_RS09325 1841830..1842057 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZS66_RS09330 1842210..1842581 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZS66_RS09335 1842571..1842918 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZS66_RS09340 1843199..1843444 - 246 WP_011285304.1 hypothetical protein -
DZS66_RS09345 1843419..1843694 - 276 WP_014407964.1 hypothetical protein -
DZS66_RS09350 1843684..1844022 - 339 WP_030126557.1 replication protein -
DZS66_RS09355 1844064..1844330 - 267 WP_011285307.1 hypothetical protein -
DZS66_RS09360 1844327..1845115 - 789 WP_011285308.1 hypothetical protein -
DZS66_RS09745 1845206..1845364 - 159 WP_011285309.1 hypothetical protein -
DZS66_RS09365 1845378..1845623 - 246 WP_011285310.1 hypothetical protein -
DZS66_RS09370 1845619..1845945 - 327 Protein_1745 hypothetical protein -
DZS66_RS09750 1845947..1846120 - 174 WP_011285312.1 hypothetical protein -
DZS66_RS09375 1846126..1846299 - 174 WP_129851225.1 DUF2758 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109579 WP_014407961.1 NZ_CP031627:c1841840-1841571 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109579 NZ_CP031627:c1841840-1841571 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109579 WP_014407962.1 NZ_CP031627:c1842057-1841830 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109579 NZ_CP031627:c1842057-1841830 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References