Detailed information of TA system TA109577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1841798..1842284
• Replicon: chromosome
• Accession: NZ_CP031625
• Organism: Streptococcus pyogenes strain MGAS28533

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: DZU27_RS09405
• Protein ID: WP_014407961.1
• Coordinates: 1841798..1842067 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: DZU27_RS09410
• Protein ID: WP_014407962.1
• Coordinates: 1842057..1842284 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZU27_RS09390	1837293..1838366	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
DZU27_RS09395	1838483..1840756	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
DZU27_RS09400	1840891..1841424	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
DZU27_RS09405	1841798..1842067	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZU27_RS09410	1842057..1842284	-	228	WP_014407962.1	hypothetical protein	Antitoxin
DZU27_RS09415	1842437..1842808	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
DZU27_RS09420	1842798..1843145	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
DZU27_RS09425	1843426..1843671	-	246	WP_011285304.1	hypothetical protein	-
DZU27_RS09430	1843646..1843921	-	276	WP_014407964.1	hypothetical protein	-
DZU27_RS09435	1843911..1844249	-	339	WP_030126557.1	replication protein	-
DZU27_RS09440	1844291..1844557	-	267	WP_011285307.1	hypothetical protein	-
DZU27_RS09445	1844554..1845342	-	789	WP_011285308.1	hypothetical protein	-
DZU27_RS09830	1845433..1845591	-	159	WP_011285309.1	hypothetical protein	-
DZU27_RS09450	1845605..1845850	-	246	WP_011285310.1	hypothetical protein	-
DZU27_RS09455	1845846..1846172	-	327	Protein_1755	hypothetical protein	-
DZU27_RS09835	1846174..1846347	-	174	WP_011285312.1	hypothetical protein	-
DZU27_RS09460	1846353..1846526	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T109577 WP_014407961.1 NZ_CP031625:c1842067-1841798 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T109577 NZ_CP031625:c1842067-1841798 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT109577 WP_014407962.1 NZ_CP031625:c1842284-1842057 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT109577 NZ_CP031625:c1842284-1842057 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7