Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1853584..1854070 Replicon chromosome
Accession NZ_CP031623
Organism Streptococcus pyogenes strain MGAS28669

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZV55_RS09440 Protein ID WP_014407961.1
Coordinates 1853584..1853853 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZV55_RS09445 Protein ID WP_014407962.1
Coordinates 1853843..1854070 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZV55_RS09425 1849079..1850152 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZV55_RS09430 1850269..1852542 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZV55_RS09435 1852677..1853210 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZV55_RS09440 1853584..1853853 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZV55_RS09445 1853843..1854070 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZV55_RS09450 1854223..1854594 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZV55_RS09455 1854584..1854931 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZV55_RS09460 1855212..1855457 - 246 WP_011285304.1 hypothetical protein -
DZV55_RS09465 1855432..1855707 - 276 WP_014407964.1 hypothetical protein -
DZV55_RS09470 1855697..1856035 - 339 WP_030126557.1 replication protein -
DZV55_RS09475 1856077..1856343 - 267 WP_011285307.1 hypothetical protein -
DZV55_RS09480 1856340..1857128 - 789 WP_011285308.1 hypothetical protein -
DZV55_RS09870 1857219..1857377 - 159 WP_011285309.1 hypothetical protein -
DZV55_RS09485 1857391..1857636 - 246 WP_011285310.1 hypothetical protein -
DZV55_RS09490 1857632..1857958 - 327 Protein_1763 hypothetical protein -
DZV55_RS09875 1857960..1858133 - 174 WP_011285312.1 hypothetical protein -
DZV55_RS09495 1858139..1858312 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109575 WP_014407961.1 NZ_CP031623:c1853853-1853584 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109575 NZ_CP031623:c1853853-1853584 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109575 WP_014407962.1 NZ_CP031623:c1854070-1853843 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109575 NZ_CP031623:c1854070-1853843 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References