Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1802157..1802643 Replicon chromosome
Accession NZ_CP031621
Organism Streptococcus pyogenes strain MGAS28746

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZW30_RS09080 Protein ID WP_014407961.1
Coordinates 1802157..1802426 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZW30_RS09085 Protein ID WP_014407962.1
Coordinates 1802416..1802643 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZW30_RS09065 1797652..1798725 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZW30_RS09070 1798842..1801115 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZW30_RS09075 1801250..1801783 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZW30_RS09080 1802157..1802426 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZW30_RS09085 1802416..1802643 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZW30_RS09090 1802796..1803167 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZW30_RS09095 1803157..1803504 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZW30_RS09100 1803785..1804030 - 246 WP_011285304.1 hypothetical protein -
DZW30_RS09105 1804005..1804280 - 276 WP_014407964.1 hypothetical protein -
DZW30_RS09110 1804270..1804608 - 339 WP_030126557.1 replication protein -
DZW30_RS09115 1804650..1804916 - 267 WP_011285307.1 hypothetical protein -
DZW30_RS09120 1804913..1805701 - 789 WP_011285308.1 hypothetical protein -
DZW30_RS09490 1805792..1805950 - 159 WP_011285309.1 hypothetical protein -
DZW30_RS09125 1805964..1806209 - 246 WP_011285310.1 hypothetical protein -
DZW30_RS09130 1806205..1806531 - 327 Protein_1690 hypothetical protein -
DZW30_RS09495 1806533..1806706 - 174 WP_011285312.1 hypothetical protein -
DZW30_RS09135 1806712..1806885 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109573 WP_014407961.1 NZ_CP031621:c1802426-1802157 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109573 NZ_CP031621:c1802426-1802157 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109573 WP_014407962.1 NZ_CP031621:c1802643-1802416 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109573 NZ_CP031621:c1802643-1802416 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References