Detailed information of TA system TA109573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1802157..1802643
• Replicon: chromosome
• Accession: NZ_CP031621
• Organism: Streptococcus pyogenes strain MGAS28746

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: DZW30_RS09080
• Protein ID: WP_014407961.1
• Coordinates: 1802157..1802426 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: DZW30_RS09085
• Protein ID: WP_014407962.1
• Coordinates: 1802416..1802643 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZW30_RS09065	1797652..1798725	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
DZW30_RS09070	1798842..1801115	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
DZW30_RS09075	1801250..1801783	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
DZW30_RS09080	1802157..1802426	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZW30_RS09085	1802416..1802643	-	228	WP_014407962.1	hypothetical protein	Antitoxin
DZW30_RS09090	1802796..1803167	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
DZW30_RS09095	1803157..1803504	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
DZW30_RS09100	1803785..1804030	-	246	WP_011285304.1	hypothetical protein	-
DZW30_RS09105	1804005..1804280	-	276	WP_014407964.1	hypothetical protein	-
DZW30_RS09110	1804270..1804608	-	339	WP_030126557.1	replication protein	-
DZW30_RS09115	1804650..1804916	-	267	WP_011285307.1	hypothetical protein	-
DZW30_RS09120	1804913..1805701	-	789	WP_011285308.1	hypothetical protein	-
DZW30_RS09490	1805792..1805950	-	159	WP_011285309.1	hypothetical protein	-
DZW30_RS09125	1805964..1806209	-	246	WP_011285310.1	hypothetical protein	-
DZW30_RS09130	1806205..1806531	-	327	Protein_1690	hypothetical protein	-
DZW30_RS09495	1806533..1806706	-	174	WP_011285312.1	hypothetical protein	-
DZW30_RS09135	1806712..1806885	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T109573 WP_014407961.1 NZ_CP031621:c1802426-1802157 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T109573 NZ_CP031621:c1802426-1802157 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT109573 WP_014407962.1 NZ_CP031621:c1802643-1802416 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT109573 NZ_CP031621:c1802643-1802416 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7