Detailed information of TA system TA109572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1788383..1788869
• Replicon: chromosome
• Accession: NZ_CP031620
• Organism: Streptococcus pyogenes strain MGAS29064

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: DZY54_RS08960
• Protein ID: WP_014407961.1
• Coordinates: 1788383..1788652 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: DZY54_RS08965
• Protein ID: WP_014407962.1
• Coordinates: 1788642..1788869 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZY54_RS08945	1783878..1784951	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
DZY54_RS08950	1785068..1787341	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
DZY54_RS08955	1787476..1788009	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
DZY54_RS08960	1788383..1788652	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZY54_RS08965	1788642..1788869	-	228	WP_014407962.1	hypothetical protein	Antitoxin
DZY54_RS08970	1789022..1789393	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
DZY54_RS08975	1789383..1789730	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
DZY54_RS08980	1790011..1790256	-	246	WP_011285304.1	hypothetical protein	-
DZY54_RS08985	1790231..1790506	-	276	WP_014407964.1	hypothetical protein	-
DZY54_RS08990	1790496..1790834	-	339	WP_030126557.1	replication protein	-
DZY54_RS08995	1790876..1791142	-	267	WP_011285307.1	hypothetical protein	-
DZY54_RS09000	1791139..1791927	-	789	WP_011285308.1	hypothetical protein	-
DZY54_RS09360	1792018..1792176	-	159	WP_011285309.1	hypothetical protein	-
DZY54_RS09005	1792190..1792435	-	246	WP_011285310.1	hypothetical protein	-
DZY54_RS09010	1792431..1792757	-	327	Protein_1665	hypothetical protein	-
DZY54_RS09365	1792759..1792932	-	174	WP_011285312.1	hypothetical protein	-
DZY54_RS09015	1792938..1793111	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T109572 WP_014407961.1 NZ_CP031620:c1788652-1788383 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T109572 NZ_CP031620:c1788652-1788383 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT109572 WP_014407962.1 NZ_CP031620:c1788869-1788642 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT109572 NZ_CP031620:c1788869-1788642 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7