Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1894799..1895285 Replicon chromosome
Accession NZ_CP031619
Organism Streptococcus pyogenes strain MGAS29284

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZ066_RS09750 Protein ID WP_014407961.1
Coordinates 1894799..1895068 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZ066_RS09755 Protein ID WP_014407962.1
Coordinates 1895058..1895285 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ066_RS09735 1890294..1891367 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZ066_RS09740 1891484..1893757 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZ066_RS09745 1893892..1894425 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZ066_RS09750 1894799..1895068 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZ066_RS09755 1895058..1895285 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZ066_RS09760 1895438..1895809 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZ066_RS09765 1895799..1896146 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZ066_RS09770 1896427..1896672 - 246 WP_011285304.1 hypothetical protein -
DZ066_RS09775 1896647..1896922 - 276 WP_014407964.1 hypothetical protein -
DZ066_RS09780 1896912..1897250 - 339 WP_030126557.1 replication protein -
DZ066_RS09785 1897292..1897558 - 267 WP_011285307.1 hypothetical protein -
DZ066_RS09790 1897555..1898343 - 789 WP_011285308.1 hypothetical protein -
DZ066_RS10180 1898434..1898592 - 159 WP_011285309.1 hypothetical protein -
DZ066_RS09795 1898606..1898851 - 246 WP_011285310.1 hypothetical protein -
DZ066_RS09800 1898847..1899173 - 327 Protein_1825 hypothetical protein -
DZ066_RS10185 1899175..1899348 - 174 WP_011285312.1 hypothetical protein -
DZ066_RS09805 1899354..1899527 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109571 WP_014407961.1 NZ_CP031619:c1895068-1894799 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109571 NZ_CP031619:c1895068-1894799 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109571 WP_014407962.1 NZ_CP031619:c1895285-1895058 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109571 NZ_CP031619:c1895285-1895058 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References