109570

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1676758..1677370 Replicon chromosome
Accession NZ_CP031619
Organism Streptococcus pyogenes strain MGAS29284

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag DZ066_RS08670 Protein ID WP_000384858.1
Coordinates 1677035..1677370 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag DZ066_RS08665 Protein ID WP_000255538.1
Coordinates 1676758..1677045 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ066_RS08640 1672290..1672718 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DZ066_RS08645 1673164..1673937 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DZ066_RS08650 1674637..1674873 + 237 WP_011285172.1 hypothetical protein -
DZ066_RS08655 1674863..1675198 + 336 WP_011285173.1 type II toxin-antitoxin system RelE/ParE family toxin -
DZ066_RS10200 1675326..1675820 + 495 WP_030126596.1 site-specific integrase -
DZ066_RS10205 1675783..1676145 + 363 WP_180372423.1 tyrosine-type recombinase/integrase -
DZ066_RS10210 1676181..1676330 + 150 WP_011285175.1 integrase -
DZ066_RS08665 1676758..1677045 + 288 WP_000255538.1 hypothetical protein Antitoxin
DZ066_RS08670 1677035..1677370 + 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZ066_RS08675 1677675..1678145 - 471 WP_000130119.1 hypothetical protein -
DZ066_RS08680 1678313..1679569 - 1257 WP_000122832.1 plasmid recombination protein -
DZ066_RS08685 1679885..1680319 - 435 WP_001220479.1 hypothetical protein -
DZ066_RS08690 1680355..1681230 - 876 WP_000770113.1 hypothetical protein -
DZ066_RS08695 1681543..1682172 - 630 WP_000591148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T109570 WP_000384858.1 NZ_CP031619:1677035-1677370 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T109570 NZ_CP031619:1677035-1677370 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT109570 WP_000255538.1 NZ_CP031619:1676758-1677045 [Streptococcus pyogenes]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT109570 NZ_CP031619:1676758-1677045 [Streptococcus pyogenes]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References