Detailed information of TA system TA109569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1889197..1889683
• Replicon: chromosome
• Accession: NZ_CP031618
• Organism: Streptococcus pyogenes strain MGAS29326

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: DZ106_RS09575
• Protein ID: WP_014407961.1
• Coordinates: 1889197..1889466 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: DZ106_RS09580
• Protein ID: WP_014407962.1
• Coordinates: 1889456..1889683 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZ106_RS09560	1884692..1885765	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
DZ106_RS09565	1885882..1888155	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
DZ106_RS09570	1888290..1888823	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
DZ106_RS09575	1889197..1889466	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZ106_RS09580	1889456..1889683	-	228	WP_014407962.1	hypothetical protein	Antitoxin
DZ106_RS09585	1889836..1890207	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
DZ106_RS09590	1890197..1890544	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
DZ106_RS09595	1890825..1891070	-	246	WP_011285304.1	hypothetical protein	-
DZ106_RS09600	1891045..1891320	-	276	WP_014407964.1	hypothetical protein	-
DZ106_RS09605	1891310..1891648	-	339	WP_030126557.1	replication protein	-
DZ106_RS09610	1891690..1891956	-	267	WP_011285307.1	hypothetical protein	-
DZ106_RS09615	1891953..1892741	-	789	WP_011285308.1	hypothetical protein	-
DZ106_RS09990	1892832..1892990	-	159	WP_011285309.1	hypothetical protein	-
DZ106_RS09620	1893004..1893249	-	246	WP_011285310.1	hypothetical protein	-
DZ106_RS09625	1893245..1893571	-	327	Protein_1787	hypothetical protein	-
DZ106_RS09995	1893573..1893746	-	174	WP_011285312.1	hypothetical protein	-
DZ106_RS09630	1893752..1893925	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T109569 WP_014407961.1 NZ_CP031618:c1889466-1889197 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T109569 NZ_CP031618:c1889466-1889197 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT109569 WP_014407962.1 NZ_CP031618:c1889683-1889456 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT109569 NZ_CP031618:c1889683-1889456 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7