Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1842570..1843056 Replicon chromosome
Accession NZ_CP031617
Organism Streptococcus pyogenes strain MGAS29409

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZ187_RS09355 Protein ID WP_014407961.1
Coordinates 1842570..1842839 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZ187_RS09360 Protein ID WP_014407962.1
Coordinates 1842829..1843056 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ187_RS09340 1838065..1839138 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZ187_RS09345 1839255..1841528 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZ187_RS09350 1841663..1842196 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZ187_RS09355 1842570..1842839 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZ187_RS09360 1842829..1843056 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZ187_RS09365 1843209..1843580 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZ187_RS09370 1843570..1843917 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZ187_RS09375 1844198..1844443 - 246 WP_011285304.1 hypothetical protein -
DZ187_RS09380 1844418..1844693 - 276 WP_014407964.1 hypothetical protein -
DZ187_RS09385 1844683..1845021 - 339 WP_030126557.1 replication protein -
DZ187_RS09390 1845063..1845329 - 267 WP_011285307.1 hypothetical protein -
DZ187_RS09395 1845326..1846114 - 789 WP_011285308.1 hypothetical protein -
DZ187_RS09775 1846205..1846363 - 159 WP_011285309.1 hypothetical protein -
DZ187_RS09400 1846377..1846622 - 246 WP_011285310.1 hypothetical protein -
DZ187_RS09405 1846618..1846944 - 327 Protein_1745 hypothetical protein -
DZ187_RS09780 1846946..1847119 - 174 WP_011285312.1 hypothetical protein -
DZ187_RS09410 1847125..1847298 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109568 WP_014407961.1 NZ_CP031617:c1842839-1842570 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109568 NZ_CP031617:c1842839-1842570 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109568 WP_014407962.1 NZ_CP031617:c1843056-1842829 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109568 NZ_CP031617:c1843056-1842829 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References