Detailed information of TA system TA109519

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2637604..2638274
• Replicon: chromosome
• Accession: NZ_CP031607
• Organism: Xanthomonas hortorum strain VT106

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DYQ48_RS11395
• Protein ID: WP_104591581.1
• Coordinates: 2637604..2638023 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DYQ48_RS11400
• Protein ID: WP_154844660.1
• Coordinates: 2638020..2638274 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYQ48_RS11355	2633527..2633805	+	279	WP_154844652.1	DUF2285 domain-containing protein	-
DYQ48_RS11360	2633817..2634116	+	300	WP_168952532.1	XRE family transcriptional regulator	-
DYQ48_RS11365	2634113..2634301	+	189	WP_154844654.1	hypothetical protein	-
DYQ48_RS11370	2634371..2634628	-	258	WP_154844655.1	hypothetical protein	-
DYQ48_RS11375	2634641..2634886	-	246	WP_154844656.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
DYQ48_RS11380	2634953..2636425	-	1473	WP_154844657.1	P-type conjugative transfer protein TrbL	-
DYQ48_RS11385	2636422..2636652	-	231	WP_154844658.1	entry exclusion lipoprotein TrbK	-
DYQ48_RS11390	2636665..2637447	-	783	WP_154844659.1	P-type conjugative transfer protein TrbJ	-
DYQ48_RS11395	2637604..2638023	-	420	WP_104591581.1	type II toxin-antitoxin system VapC family toxin	Toxin
DYQ48_RS11400	2638020..2638274	-	255	WP_154844660.1	Arc family DNA-binding protein	Antitoxin
DYQ48_RS11405	2638686..2638967	-	282	WP_154844661.1	TraK family protein	-
DYQ48_RS11410	2639585..2640472	-	888	WP_180334452.1	replication protein C	-
DYQ48_RS11415	2640444..2641322	-	879	WP_154844662.1	helicase RepA family protein	-
DYQ48_RS11420	2641326..2641559	-	234	WP_003472509.1	hypothetical protein	-
DYQ48_RS11425	2641641..2642630	+	990	WP_104591591.1	LuxR family transcriptional regulator	-
DYQ48_RS11430	2642710..2642955	+	246	WP_104591592.1	AlpA family phage regulatory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2635082..2674143	39061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14935.15 Da
• Isoelectric Point: 4.9167

>T109519 WP_104591581.1 NZ_CP031607:c2638023-2637604 [Xanthomonas hortorum]
MIVLDTNVVSEAMKSEPDPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFSERVLMFDTE
AARNYAELAVKARIAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHR

Nucleotide

• Length: 420 bp

>T109519 NZ_CP031607:c2638023-2637604 [Xanthomonas hortorum]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAATCCGAACCCGACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTTGCCGAACTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAAAAAGGCCTGGGCGAAGCCCTGGACGGATTGCTCGAACTGTTCAGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCAATTATGCCGAGCTGGCGGTGAAGGCCCGCATAGCCGGGAAGGGTTTTCCAACACCCGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTTGAAGCGGCCGGGCTTACCGTTATCA
ATCCTTGGAACCATCGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9472.88 Da
• Isoelectric Point: 5.7425

>AT109519 WP_154844660.1 NZ_CP031607:c2638274-2638020 [Xanthomonas hortorum]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKLEKRIRMGDALAELGRQVGLTNDDLAVLDQVRDKVPAEP
MRFE

Nucleotide

• Length: 255 bp

>AT109519 NZ_CP031607:c2638274-2638020 [Xanthomonas hortorum]
ATGGCAATCCTGACAGTGCGGAATGTGCCCGACGAGGTGCATCGCGCTCTGCGCTTACGGGCAGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTCCGCGAGATTCTGGAGAGTGCAGTTAAGTTAGAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCAAGTAGGGCTGACAAACGATGATCTCGCAGTGTTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA