Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 1994893..1995446 Replicon chromosome
Accession NZ_CP031606
Organism Pseudomonas sp. phDV1

Toxin (Protein)


Gene name parE Uniprot ID A0A385B7Q1
Locus tag DZC76_RS09535 Protein ID WP_003461247.1
Coordinates 1995153..1995446 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W6RG82
Locus tag DZC76_RS09530 Protein ID WP_003461245.1
Coordinates 1994893..1995165 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZC76_RS22930 1990195..1990944 + 750 WP_162884220.1 hypothetical protein -
DZC76_RS09515 1991423..1992178 - 756 WP_116618504.1 IS21-like element ISPpu7 family helper ATPase IstB -
DZC76_RS09520 1992196..1993710 - 1515 WP_019437638.1 IS21-like element ISPpu7 family transposase -
DZC76_RS09525 1994231..1994560 + 330 Protein_1819 group II intron reverse transcriptase/maturase -
DZC76_RS09530 1994893..1995165 + 273 WP_003461245.1 CopG family ribbon-helix-helix protein Antitoxin
DZC76_RS09535 1995153..1995446 + 294 WP_003461247.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZC76_RS09540 1995440..1996114 - 675 Protein_1822 site-specific integrase -
DZC76_RS09545 1996043..1996447 + 405 Protein_1823 DUF262 domain-containing protein -
DZC76_RS09555 1996626..1997915 + 1290 WP_116618506.1 FAD-binding oxidoreductase -
DZC76_RS09560 1997932..1998489 + 558 WP_021489866.1 helix-turn-helix domain-containing protein -
DZC76_RS09565 1998519..1999865 + 1347 WP_100547961.1 glutamine synthetase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1918083..2019004 100921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11183.67 Da        Isoelectric Point: 5.9081

>T109515 WP_003461247.1 NZ_CP031606:1995153-1995446 [Pseudomonas sp. phDV1]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRVAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T109515 NZ_CP031606:1995153-1995446 [Pseudomonas sp. phDV1]
GTGCCACGATTGATTGTTACTGAAGGCGCGGCGAAGGGCTTGGAGCGTTGCCGGCGATTCCTCTCAGACAAAGATCCGCA
GGTCGCGCGCCGTGTTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCATTTC
CAGATCTGCCGGAGCTGCGTGAGCTCATCATCGAATTTGGTGACTCAGGTTACGTAGCGTTGTACCGCTATGAGCGTGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10477.71 Da        Isoelectric Point: 6.7193

>AT109515 WP_003461245.1 NZ_CP031606:1994893-1995165 [Pseudomonas sp. phDV1]
MATSIKIDDKLKGRILQLASQRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTSQETRAWLGSWGTD
TEVELPKCHD

Download         Length: 273 bp

>AT109515 NZ_CP031606:1994893-1995165 [Pseudomonas sp. phDV1]
ATGGCCACTTCCATCAAAATTGATGACAAGCTAAAAGGCCGCATTCTGCAGTTGGCGAGCCAACGCCAGCGCTCGTCTCA
CTGGATCATGCGCGAGGCAATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAGCAGGAAGCCCTGGCAT
CGTGGGCGGCATATCAGGAAACCGGACGGCATTTGACCAGCCAAGAAACTCGGGCCTGGCTCGGTAGCTGGGGAACAGAT
ACTGAGGTAGAGCTTCCCAAGTGCCACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A385B7Q1

Antitoxin

Source ID Structure
AlphaFold DB W6RG82

References