Detailed information of TA system TA109514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1280953..1282160
• Replicon: chromosome
• Accession: NZ_CP031606
• Organism: Pseudomonas sp. phDV1

Toxin (Protein)

• Gene name: -
• Uniprot ID: W6QUQ8
• Locus tag: DZC76_RS05995
• Protein ID: WP_003462580.1
• Coordinates: 1281408..1282160 (+)
• Length: 251 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W6QTC2
• Locus tag: DZC76_RS05990
• Protein ID: WP_003462583.1
• Coordinates: 1280953..1281324 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZC76_RS05965	1276636..1276962	+	327	WP_003246056.1	Grx4 family monothiol glutaredoxin	-
DZC76_RS05975	1277699..1278037	-	339	WP_074860036.1	YdbL family protein	-
DZC76_RS05980	1278069..1278260	-	192	WP_017675074.1	YnbE family lipoprotein	-
DZC76_RS05985	1278265..1280820	-	2556	WP_116618075.1	YdbH domain-containing protein	-
DZC76_RS05990	1280953..1281324	+	372	WP_003462583.1	XRE family transcriptional regulator	Antitoxin
DZC76_RS05995	1281408..1282160	+	753	WP_003462580.1	RES family NAD+ phosphorylase	Toxin
DZC76_RS06000	1282598..1282849	+	252	WP_017675070.1	sel1 repeat family protein	-
DZC76_RS06005	1283029..1284390	+	1362	WP_162884251.1	DNA recombination protein RmuC	-
DZC76_RS06010	1284405..1285352	-	948	WP_116618076.1	alpha/beta fold hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-206)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (72-121)

Sequences

Toxin

Protein

• Length: 251 a.a.
• Molecular weight: 28505.52 Da
• Isoelectric Point: 7.5090

>T109514 WP_003462580.1 NZ_CP031606:1281408-1282160 [Pseudomonas sp. phDV1]
MDIWQLCDGERQVRPLRGKLLRMVESQAQVATLQLVDNLAEQTLLEELLESSKPPLPEAAEPLHYLLKTPFRYPPLRWGS
RFGRVHEPSLFYAAQRLQTAMAEAAYYRFVLWNGMVVPPPSGRILSEHSTFEARYRVEHGIQLQQSPFAQHDALLAHPSD
YSVPQRLGTSMRAAGIQAFEYRSARCPDGGSNVALYVPAAFVEKRPRNLTAWLCETTSEYVAFKHAQTPDQPRLFHWEQF
LVQGQLPHPA

Nucleotide

• Length: 753 bp

>T109514 NZ_CP031606:1281408-1282160 [Pseudomonas sp. phDV1]
ATGGATATCTGGCAACTATGCGACGGCGAGCGACAGGTGCGACCGCTGCGCGGCAAGCTGTTGCGCATGGTGGAGAGCCA
GGCCCAGGTTGCGACCCTGCAACTGGTGGATAACCTGGCCGAGCAGACCCTGCTCGAGGAACTGCTCGAGAGCAGCAAGC
CGCCGCTGCCTGAAGCCGCCGAGCCGTTGCACTACCTGCTGAAGACGCCGTTTCGTTATCCGCCGCTGCGTTGGGGCTCG
CGCTTCGGCCGCGTGCACGAACCCAGCCTGTTCTACGCCGCTCAGCGTCTGCAAACGGCGATGGCCGAGGCCGCCTACTA
CCGTTTCGTATTGTGGAATGGCATGGTCGTGCCGCCGCCCAGTGGCCGCATCCTCTCCGAGCATTCGACCTTCGAGGCGC
GTTACCGCGTCGAGCACGGTATCCAGTTGCAACAGTCGCCTTTCGCTCAACATGACGCACTGTTGGCTCACCCCAGTGAT
TACAGCGTGCCTCAGCGTCTCGGTACGTCGATGCGCGCGGCGGGCATTCAGGCTTTCGAGTACCGCTCGGCACGCTGTCC
TGACGGTGGCAGCAATGTGGCGCTCTACGTGCCGGCTGCGTTCGTGGAGAAGCGTCCGCGTAATCTGACGGCCTGGTTGT
GTGAAACCACGAGCGAGTACGTGGCGTTCAAGCATGCGCAAACGCCGGATCAACCACGGCTGTTTCACTGGGAGCAGTTT
CTGGTGCAGGGGCAATTGCCGCACCCCGCGTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13661.73 Da
• Isoelectric Point: 10.6604

>AT109514 WP_003462583.1 NZ_CP031606:1280953-1281324 [Pseudomonas sp. phDV1]
MSAVTRSQPDADAVLAKALLNTREQLGLTQQELADIVGVHRSAISRWSEQGGLRPQSKTGELALLLIRAYRALFALFGGN
QQDMRHFLRTENRHLAGIPLQQMSQVQGLVRVVEYLDAIRGKV

Nucleotide

• Length: 372 bp

>AT109514 NZ_CP031606:1280953-1281324 [Pseudomonas sp. phDV1]
ATGAGTGCTGTGACTCGCTCTCAGCCCGATGCCGATGCGGTACTGGCTAAAGCCCTGCTCAATACCCGTGAGCAACTGGG
GCTGACGCAGCAGGAGCTGGCCGACATCGTTGGCGTCCATCGCAGTGCCATCAGCCGCTGGAGTGAGCAGGGTGGTTTGC
GTCCGCAGAGCAAGACCGGCGAGCTGGCGCTGTTGCTGATACGCGCCTATCGCGCGCTGTTTGCCCTGTTTGGCGGCAAT
CAGCAGGACATGCGCCATTTTCTGCGCACCGAAAATCGCCATCTGGCAGGTATTCCGCTGCAGCAGATGAGTCAGGTGCA
GGGGCTGGTGCGTGTTGTCGAGTATCTGGACGCCATTCGCGGCAAGGTCTGA

Structures

Toxin

• AlphaFold DB: W6QUQ8

Antitoxin

• AlphaFold DB: W6QTC2