Detailed information of TA system TA109511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 741839..742380
• Replicon: chromosome
• Accession: NZ_CP031606
• Organism: Pseudomonas sp. phDV1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W6QQQ0
• Locus tag: DZC76_RS03360
• Protein ID: WP_039965077.1
• Coordinates: 741839..742135 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DZC76_RS03365
• Protein ID: WP_116617865.1
• Coordinates: 742123..742380 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZC76_RS03330	737443..737586	+	144	WP_116617861.1	DUF2474 domain-containing protein	-
DZC76_RS03335	737677..737970	+	294	Protein_654	aldehyde dehydrogenase family protein	-
DZC76_RS03345	738349..738819	-	471	WP_162884207.1	hypothetical protein	-
DZC76_RS03350	739074..740516	+	1443	WP_116617864.1	TldD/PmbA family protein	-
DZC76_RS03355	740516..741835	+	1320	WP_004425062.1	Zn-dependent protease	-
DZC76_RS03360	741839..742135	-	297	WP_039965077.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZC76_RS03365	742123..742380	-	258	WP_116617865.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DZC76_RS03370	742449..743573	-	1125	WP_004425056.1	class I SAM-dependent methyltransferase	-
DZC76_RS03375	743817..744593	+	777	WP_116617866.1	ferredoxin--NADP reductase	-
DZC76_RS03380	744594..745619	-	1026	WP_116617867.1	hemolysin family protein	-
DZC76_RS03385	745860..746108	+	249	WP_004425048.1	YdcH family protein	-
DZC76_RS03390	746177..746455	+	279	WP_004425044.1	DUF465 domain-containing protein	-
DZC76_RS03395	746717..747193	-	477	WP_116617868.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11393.23 Da
• Isoelectric Point: 5.5623

>T109511 WP_039965077.1 NZ_CP031606:c742135-741839 [Pseudomonas sp. phDV1]
MAEIVWTNTALEQLDDLAHYIALDKPDAARALVMRAVETVSRLADFPLSGRVPDELPHSVYREIVIPPCRIFYRYTDTTV
FIIHIMREERVLRAHMLE

Nucleotide

• Length: 297 bp

>T109511 NZ_CP031606:c742135-741839 [Pseudomonas sp. phDV1]
ATGGCTGAAATAGTCTGGACGAACACCGCCCTCGAGCAGCTCGACGATCTCGCGCACTACATCGCCCTCGACAAACCGGA
CGCCGCGCGAGCGCTGGTCATGAGGGCCGTTGAAACGGTTTCACGGTTAGCAGACTTTCCCCTGTCGGGCCGCGTTCCGG
ATGAGCTTCCACACTCGGTGTACCGCGAAATCGTCATCCCACCCTGCCGAATTTTCTACCGTTATACAGACACAACGGTT
TTCATCATCCACATCATGCGAGAGGAGCGCGTGCTGCGCGCCCACATGCTCGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9772.28 Da
• Isoelectric Point: 7.3181

>AT109511 WP_116617865.1 NZ_CP031606:c742380-742123 [Pseudomonas sp. phDV1]
MKVELVTNLKRQATKILADLHESKEPVLITEHGMPSAYLVDVDDYQFMQKRLALLDALARGERAVIEGNTQNHEQAKERL
SKWLK

Nucleotide

• Length: 258 bp

>AT109511 NZ_CP031606:c742380-742123 [Pseudomonas sp. phDV1]
ATGAAAGTCGAGTTGGTCACCAACCTGAAGCGGCAAGCCACCAAGATTCTGGCCGACCTTCACGAGTCCAAAGAGCCCGT
ACTGATCACCGAGCATGGAATGCCCTCGGCTTATCTGGTGGATGTCGATGATTATCAGTTCATGCAGAAGCGTCTTGCCC
TTCTGGATGCACTGGCTCGCGGTGAGCGCGCCGTTATCGAGGGCAACACCCAGAACCATGAGCAGGCCAAGGAACGGCTG
AGCAAATGGCTGAAATAG

Structures

Toxin

• AlphaFold DB: W6QQQ0