Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1090035..1090559 Replicon chromosome
Accession NZ_CP031605
Organism Staphylococcus pseudintermedius strain VB16

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag DRC71_RS04900 Protein ID WP_014613379.1
Coordinates 1090206..1090559 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag DRC71_RS04895 Protein ID WP_014613378.1
Coordinates 1090035..1090205 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRC71_RS04870 (DRC71_04955) 1085924..1086397 + 474 WP_014613373.1 PH domain-containing protein -
DRC71_RS04875 (DRC71_04960) 1086390..1087919 + 1530 WP_096533708.1 PH domain-containing protein -
DRC71_RS04880 (DRC71_04965) 1087903..1088421 + 519 WP_065354119.1 PH domain-containing protein -
DRC71_RS04885 (DRC71_04970) 1088418..1088768 + 351 WP_014613376.1 holo-ACP synthase -
DRC71_RS04890 (DRC71_04975) 1088802..1089950 + 1149 WP_014613377.1 alanine racemase -
DRC71_RS04895 (DRC71_04980) 1090035..1090205 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DRC71_RS04900 (DRC71_04985) 1090206..1090559 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DRC71_RS04905 (DRC71_04990) 1090617..1091621 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
DRC71_RS04910 (DRC71_04995) 1091700..1092026 + 327 WP_014613381.1 anti-sigma factor antagonist -
DRC71_RS04915 (DRC71_05000) 1092026..1092505 + 480 WP_031253870.1 anti-sigma B factor RsbW -
DRC71_RS04920 (DRC71_05005) 1092480..1093250 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T109509 WP_014613379.1 NZ_CP031605:1090206-1090559 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T109509 NZ_CP031605:1090206-1090559 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT109509 WP_014613378.1 NZ_CP031605:1090035-1090205 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT109509 NZ_CP031605:1090035-1090205 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References