Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1073786..1074307 Replicon chromosome
Accession NZ_CP031605
Organism Staphylococcus pseudintermedius strain VB16

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag DRC71_RS04820 Protein ID WP_014613364.1
Coordinates 1074086..1074307 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag DRC71_RS04815 Protein ID WP_014613363.1
Coordinates 1073786..1074073 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRC71_RS04790 (DRC71_04875) 1069047..1069850 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
DRC71_RS04795 (DRC71_04880) 1069840..1070478 + 639 WP_014613359.1 thiamine phosphate synthase -
DRC71_RS04800 (DRC71_04885) 1070567..1071433 + 867 WP_014613360.1 membrane protein insertase YidC -
DRC71_RS04805 (DRC71_04890) 1071487..1072143 - 657 WP_014613361.1 HD domain-containing protein -
DRC71_RS04810 (DRC71_04895) 1072164..1073654 - 1491 WP_014613362.1 cardiolipin synthase -
DRC71_RS04815 (DRC71_04900) 1073786..1074073 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
DRC71_RS04820 (DRC71_04905) 1074086..1074307 + 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
DRC71_RS04825 (DRC71_04910) 1074311..1074517 + 207 WP_014613365.1 cation transporter -
DRC71_RS04830 (DRC71_04915) 1074618..1076798 + 2181 WP_037542539.1 heavy metal translocating P-type ATPase -
DRC71_RS04835 1076884..1077030 + 147 WP_014613367.1 Lmo0850 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T109508 WP_014613364.1 NZ_CP031605:1074086-1074307 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T109508 NZ_CP031605:1074086-1074307 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT109508 WP_014613363.1 NZ_CP031605:1073786-1074073 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT109508 NZ_CP031605:1073786-1074073 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References