Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2510714..2511238 Replicon chromosome
Accession NZ_CP031604
Organism Staphylococcus pseudintermedius strain AI14

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag DNJ55_RS11735 Protein ID WP_014613379.1
Coordinates 2510885..2511238 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag DNJ55_RS11730 Protein ID WP_014613378.1
Coordinates 2510714..2510884 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DNJ55_RS11705 (DNJ55_11820) 2506603..2507076 + 474 WP_014613373.1 PH domain-containing protein -
DNJ55_RS11710 (DNJ55_11825) 2507069..2508598 + 1530 WP_105503167.1 PH domain-containing protein -
DNJ55_RS11715 (DNJ55_11830) 2508582..2509100 + 519 WP_014613375.1 PH domain-containing protein -
DNJ55_RS11720 (DNJ55_11835) 2509097..2509447 + 351 WP_014613376.1 holo-ACP synthase -
DNJ55_RS11725 (DNJ55_11840) 2509481..2510629 + 1149 WP_065354670.1 alanine racemase -
DNJ55_RS11730 (DNJ55_11845) 2510714..2510884 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DNJ55_RS11735 (DNJ55_11850) 2510885..2511238 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DNJ55_RS11740 (DNJ55_11855) 2511296..2512300 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
DNJ55_RS11745 (DNJ55_11860) 2512379..2512705 + 327 WP_014613381.1 anti-sigma factor antagonist -
DNJ55_RS11750 (DNJ55_11865) 2512705..2513184 + 480 WP_031253870.1 anti-sigma B factor RsbW -
DNJ55_RS11755 (DNJ55_11870) 2513159..2513929 + 771 WP_105503168.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T109506 WP_014613379.1 NZ_CP031604:2510885-2511238 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T109506 NZ_CP031604:2510885-2511238 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATCCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT109506 WP_014613378.1 NZ_CP031604:2510714-2510884 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT109506 NZ_CP031604:2510714-2510884 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References