Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2495647..2496168 Replicon chromosome
Accession NZ_CP031604
Organism Staphylococcus pseudintermedius strain AI14

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag DNJ55_RS11660 Protein ID WP_014613364.1
Coordinates 2495947..2496168 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag DNJ55_RS11655 Protein ID WP_014613363.1
Coordinates 2495647..2495934 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DNJ55_RS11630 (DNJ55_11745) 2490908..2491711 + 804 WP_105503166.1 hydroxyethylthiazole kinase -
DNJ55_RS11635 (DNJ55_11750) 2491701..2492339 + 639 WP_014613359.1 thiamine phosphate synthase -
DNJ55_RS11640 (DNJ55_11755) 2492428..2493294 + 867 WP_014613360.1 membrane protein insertase YidC -
DNJ55_RS11645 (DNJ55_11760) 2493348..2494004 - 657 WP_014613361.1 HD domain-containing protein -
DNJ55_RS11650 (DNJ55_11765) 2494025..2495515 - 1491 WP_065520420.1 cardiolipin synthase -
DNJ55_RS11655 (DNJ55_11770) 2495647..2495934 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
DNJ55_RS11660 (DNJ55_11775) 2495947..2496168 + 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
DNJ55_RS11665 (DNJ55_11780) 2496172..2496378 + 207 WP_014613365.1 cation transporter -
DNJ55_RS11670 (DNJ55_11785) 2496479..2498659 + 2181 WP_096636894.1 heavy metal translocating P-type ATPase -
DNJ55_RS11675 2498745..2498891 + 147 WP_014613367.1 Lmo0850 family protein -
DNJ55_RS11680 (DNJ55_11795) 2500010..2500738 + 729 WP_014613368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T109505 WP_014613364.1 NZ_CP031604:2495947-2496168 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T109505 NZ_CP031604:2495947-2496168 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT109505 WP_014613363.1 NZ_CP031604:2495647-2495934 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT109505 NZ_CP031604:2495647-2495934 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References