Detailed information of TA system TA109498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 320810..321371
• Replicon: chromosome
• Accession: NZ_CP031598
• Organism: Roseovarius indicus strain DSM 26383

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5P3A8B3
• Locus tag: RIdsm_RS01555
• Protein ID: WP_074940361.1
• Coordinates: 320810..321085 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: RIdsm_RS01560
• Protein ID: WP_057816357.1
• Coordinates: 321078..321371 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RIdsm_RS01535	316440..317603	+	1164	WP_057816358.1	FtsH protease activity modulator HflK	-
RIdsm_RS01540	317603..318835	+	1233	WP_074940359.1	protease modulator HflC	-
RIdsm_RS01545	318832..319029	+	198	WP_082647388.1	DUF2065 domain-containing protein	-
RIdsm_RS01550	319228..320676	+	1449	WP_057816465.1	DegQ family serine endoprotease	-
RIdsm_RS01555	320810..321085	-	276	WP_074940361.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
RIdsm_RS01560	321078..321371	-	294	WP_057816357.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
RIdsm_RS01565	321486..322772	-	1287	WP_057816356.1	ABC transporter substrate-binding protein	-
RIdsm_RS29995	322843..324213	-	1371	WP_057816463.1	hypothetical protein	-
RIdsm_RS01570	324415..324699	-	285	WP_057816355.1	YrhK family protein	-
RIdsm_RS01575	324802..325875	-	1074	WP_057816354.1	phenylalanine--tRNA ligase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-58)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10189.83 Da
• Isoelectric Point: 7.4014

>T109498 WP_074940361.1 NZ_CP031598:c321085-320810 [Roseovarius indicus]
VPELEWKASAVADLMAIVDYISNDNPDAALALLEKIEARVARLAEQPKTGRPGRVHGTRELVVHHNYIVIYAERPTVVTV
LRVLHAARMWP

Nucleotide

• Length: 276 bp

>T109498 NZ_CP031598:c321085-320810 [Roseovarius indicus]
GTGCCTGAACTGGAATGGAAGGCGTCGGCGGTGGCTGACCTGATGGCCATCGTCGACTACATCTCGAACGATAACCCCGA
CGCGGCACTGGCCCTTTTGGAGAAGATCGAGGCCAGGGTGGCCCGCCTTGCCGAGCAGCCAAAGACAGGACGCCCCGGCC
GGGTTCATGGTACGCGGGAGCTGGTCGTTCACCACAATTACATCGTGATCTATGCCGAGCGCCCCACGGTGGTCACAGTG
CTGCGAGTGCTTCACGCGGCACGGATGTGGCCCTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10315.74 Da
• Isoelectric Point: 6.7249

>AT109498 WP_057816357.1 NZ_CP031598:c321371-321078 [Roseovarius indicus]
MPARTSMLHVRVDDHLKAQAAEALSGVGLTLSDAVRILLTRVAAEGGLPAGLTADPEAYDAWFRKKVQEALADTGPATPH
DEAMQDARALINRKRGA

Nucleotide

• Length: 294 bp

>AT109498 NZ_CP031598:c321371-321078 [Roseovarius indicus]
ATGCCCGCCCGAACCTCAATGCTTCATGTTCGCGTCGATGACCATTTGAAGGCGCAGGCCGCCGAAGCCCTTTCCGGCGT
CGGCCTGACTCTGTCGGATGCGGTACGTATCCTGCTGACCCGCGTGGCGGCGGAAGGGGGGCTGCCCGCGGGCCTGACCG
CCGATCCGGAGGCGTATGACGCCTGGTTTCGCAAAAAGGTTCAGGAGGCGCTGGCCGATACCGGGCCAGCGACGCCGCAT
GACGAGGCCATGCAGGATGCTCGCGCGCTGATCAACAGGAAACGCGGTGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5P3A8B3