109478

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1833952..1834468 Replicon chromosome
Accession NZ_CP031577
Organism Klebsiella pneumoniae strain N4b

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AXA58_RS09185 Protein ID WP_002886902.1
Coordinates 1833952..1834236 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AXA58_RS09190 Protein ID WP_002886901.1
Coordinates 1834226..1834468 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA58_RS09165 1829368..1829676 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
AXA58_RS31460 1829761..1829934 + 174 WP_032410138.1 hypothetical protein -
AXA58_RS09170 1829937..1830680 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
AXA58_RS09175 1831037..1833175 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AXA58_RS09180 1833484..1833948 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AXA58_RS09185 1833952..1834236 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXA58_RS09190 1834226..1834468 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AXA58_RS09195 1834546..1836456 - 1911 WP_009486549.1 BglG family transcription antiterminator -
AXA58_RS09200 1836479..1837633 - 1155 WP_023302389.1 lactonase family protein -
AXA58_RS09205 1837700..1838440 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T109478 WP_002886902.1 NZ_CP031577:c1834236-1833952 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T109478 NZ_CP031577:c1834236-1833952 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT109478 WP_002886901.1 NZ_CP031577:c1834468-1834226 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT109478 NZ_CP031577:c1834468-1834226 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References