Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1103353..1103972 Replicon chromosome
Accession NZ_CP031577
Organism Klebsiella pneumoniae strain N4b

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AXA58_RS05595 Protein ID WP_002892050.1
Coordinates 1103754..1103972 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag AXA58_RS05590 Protein ID WP_002892066.1
Coordinates 1103353..1103727 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA58_RS05580 1098505..1099698 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AXA58_RS05585 1099721..1102867 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
AXA58_RS05590 1103353..1103727 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
AXA58_RS05595 1103754..1103972 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AXA58_RS05600 1104131..1104697 + 567 WP_002892030.1 maltose O-acetyltransferase -
AXA58_RS31370 1104669..1104809 - 141 WP_004147370.1 hypothetical protein -
AXA58_RS05605 1104830..1105300 + 471 WP_002892026.1 YlaC family protein -
AXA58_RS05610 1105275..1106726 - 1452 Protein_1072 PLP-dependent aminotransferase family protein -
AXA58_RS05615 1106827..1107525 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
AXA58_RS05620 1107522..1107662 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
AXA58_RS05625 1107662..1107925 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T109475 WP_002892050.1 NZ_CP031577:1103754-1103972 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T109475 NZ_CP031577:1103754-1103972 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT109475 WP_002892066.1 NZ_CP031577:1103353-1103727 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT109475 NZ_CP031577:1103353-1103727 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References