Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3516376..3517115 Replicon chromosome
Accession NZ_CP031574
Organism Enterobacter hormaechei strain A1

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag AXA52_RS17160 Protein ID WP_003857133.1
Coordinates 3516376..3516861 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag AXA52_RS17165 Protein ID WP_003857131.1
Coordinates 3516849..3517115 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA52_RS17130 3511420..3512710 + 1291 Protein_3249 glycoside hydrolase -
AXA52_RS17135 3512710..3513324 + 615 WP_080338042.1 NUDIX hydrolase -
AXA52_RS17140 3513508..3514088 - 581 Protein_3251 DUF421 domain-containing protein -
AXA52_RS17145 3514241..3514525 - 285 Protein_3252 helix-turn-helix domain-containing protein -
AXA52_RS17150 3514775..3515740 + 966 WP_033487773.1 hypothetical protein -
AXA52_RS17155 3515756..3516325 + 570 WP_017382346.1 hypothetical protein -
AXA52_RS17160 3516376..3516861 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
AXA52_RS17165 3516849..3517115 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
AXA52_RS17170 3517179..3518071 - 893 Protein_3257 LysR family transcriptional regulator -
AXA52_RS17175 3518201..3519583 + 1383 WP_047741273.1 MFS transporter -
AXA52_RS17180 3519605..3520600 - 996 WP_023303746.1 DUF2891 domain-containing protein -
AXA52_RS17185 3520610..3521596 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T109461 WP_003857133.1 NZ_CP031574:c3516861-3516376 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T109461 NZ_CP031574:c3516861-3516376 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCTGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACATTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT109461 WP_003857131.1 NZ_CP031574:c3517115-3516849 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT109461 NZ_CP031574:c3517115-3516849 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References