Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2350928..2351548 Replicon chromosome
Accession NZ_CP031574
Organism Enterobacter hormaechei strain A1

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag AXA52_RS11495 Protein ID WP_015571250.1
Coordinates 2350928..2351146 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag AXA52_RS11500 Protein ID WP_006809850.1
Coordinates 2351174..2351548 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA52_RS11465 2346940..2347200 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
AXA52_RS11470 2347203..2347343 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AXA52_RS11475 2347340..2348050 - 711 WP_023303201.1 GNAT family N-acetyltransferase -
AXA52_RS11480 2348152..2349612 + 1461 WP_017383208.1 PLP-dependent aminotransferase family protein -
AXA52_RS11485 2349584..2350051 - 468 WP_017383209.1 membrane protein -
AXA52_RS11490 2350168..2350719 - 552 WP_116481051.1 maltose O-acetyltransferase -
AXA52_RS11495 2350928..2351146 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
AXA52_RS11500 2351174..2351548 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
AXA52_RS11505 2352059..2355205 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
AXA52_RS11510 2355228..2356421 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T109460 WP_015571250.1 NZ_CP031574:c2351146-2350928 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T109460 NZ_CP031574:c2351146-2350928 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT109460 WP_006809850.1 NZ_CP031574:c2351548-2351174 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT109460 NZ_CP031574:c2351548-2351174 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References