Detailed information of TA system TA109455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4740562..4741166
• Replicon: chromosome
• Accession: NZ_CP031571
• Organism: Enterobacter hormaechei strain N1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AXA51_RS23220
• Protein ID: WP_110292784.1
• Coordinates: 4740562..4740747 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AXA51_RS23225
• Protein ID: WP_110292783.1
• Coordinates: 4740762..4741166 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXA51_RS23205	4735881..4737719	+	1839	WP_017693788.1	selenocysteine-specific translation elongation factor	-
AXA51_RS23210	4737723..4738607	-	885	WP_015572761.1	ROK family protein	-
AXA51_RS23215	4738774..4740312	+	1539	WP_110292785.1	aldehyde dehydrogenase AldB	-
AXA51_RS23220	4740562..4740747	+	186	WP_110292784.1	type II toxin-antitoxin system HicA family toxin	Toxin
AXA51_RS23225	4740762..4741166	+	405	WP_110292783.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AXA51_RS23230	4741222..4743171	-	1950	WP_129541644.1	glycoside hydrolase family 127 protein	-
AXA51_RS23235	4743182..4744582	-	1401	WP_129541645.1	MFS transporter	-
AXA51_RS23240	4744809..4745627	+	819	WP_032649828.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6838.11 Da
• Isoelectric Point: 11.2345

>T109455 WP_110292784.1 NZ_CP031571:4740562-4740747 [Enterobacter hormaechei]
VKSADIIAVLVCHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T109455 NZ_CP031571:4740562-4740747 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATTATTGCTGTTCTGGTTTGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14990.74 Da
• Isoelectric Point: 4.3191

>AT109455 WP_110292783.1 NZ_CP031571:4740762-4741166 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGNVEVHLENHPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Nucleotide

• Length: 405 bp

>AT109455 NZ_CP031571:4740762-4741166 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAATGTCGAAGTGCACCTTGAAAATCATCCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAGTTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG