Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3440545..3441165 Replicon chromosome
Accession NZ_CP031571
Organism Enterobacter hormaechei strain N1

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag AXA51_RS17015 Protein ID WP_015571250.1
Coordinates 3440947..3441165 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag AXA51_RS17010 Protein ID WP_006809850.1
Coordinates 3440545..3440919 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA51_RS17000 3435672..3436865 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AXA51_RS17005 3436888..3440034 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
AXA51_RS17010 3440545..3440919 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
AXA51_RS17015 3440947..3441165 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
AXA51_RS17020 3441374..3441925 + 552 WP_015571251.1 maltose O-acetyltransferase -
AXA51_RS17025 3442042..3442509 + 468 WP_015571252.1 extracytoplasmic function sigma factor YlaC -
AXA51_RS17030 3442481..3443941 - 1461 WP_129541560.1 PLP-dependent aminotransferase family protein -
AXA51_RS17035 3444043..3444753 + 711 WP_110292624.1 GNAT family N-acetyltransferase -
AXA51_RS17040 3444750..3444890 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AXA51_RS17045 3444893..3445153 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T109451 WP_015571250.1 NZ_CP031571:3440947-3441165 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T109451 NZ_CP031571:3440947-3441165 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT109451 WP_006809850.1 NZ_CP031571:3440545-3440919 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT109451 NZ_CP031571:3440545-3440919 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References