Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 2862856..2863653 Replicon chromosome
Accession NZ_CP031571
Organism Enterobacter hormaechei strain N1

Toxin (Protein)


Gene name KacT Uniprot ID A0A222RDD1
Locus tag AXA51_RS14300 Protein ID WP_032647926.1
Coordinates 2862856..2863377 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag AXA51_RS14305 Protein ID WP_015570876.1
Coordinates 2863384..2863653 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA51_RS14270 2858455..2859144 + 690 WP_032653188.1 pyrimidine utilization protein B -
AXA51_RS14275 2859156..2859542 + 387 WP_015570870.1 pyrimidine utilization protein C -
AXA51_RS14280 2859550..2860350 + 801 WP_110292991.1 pyrimidine utilization protein D -
AXA51_RS14285 2860360..2860950 + 591 WP_032104810.1 malonic semialdehyde reductase -
AXA51_RS14290 2860963..2861454 + 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
AXA51_RS14295 2861476..2862797 + 1322 Protein_2761 pyrimidine utilization transport protein G -
AXA51_RS14300 2862856..2863377 - 522 WP_032647926.1 GNAT family N-acetyltransferase Toxin
AXA51_RS14305 2863384..2863653 - 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
AXA51_RS14310 2863727..2864632 - 906 WP_017693666.1 DMT family transporter -
AXA51_RS14315 2864749..2864919 - 171 WP_001273664.1 general stress protein -
AXA51_RS14320 2865311..2865907 + 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
AXA51_RS14325 2865926..2866153 + 228 WP_006809324.1 YccJ family protein -
AXA51_RS14330 2866185..2867425 - 1241 Protein_2768 bifunctional glucose-1-phosphatase/inositol phosphatase -
AXA51_RS14335 2867578..2867742 + 165 WP_017693668.1 helix-turn-helix transcriptional regulator -
AXA51_RS14340 2867752..2868111 - 360 WP_017384779.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19451.21 Da        Isoelectric Point: 7.4318

>T109450 WP_032647926.1 NZ_CP031571:c2863377-2862856 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

>T109450 NZ_CP031571:c2863377-2862856 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT109450 WP_015570876.1 NZ_CP031571:c2863653-2863384 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT109450 NZ_CP031571:c2863653-2863384 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A222RDD1

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References