Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 36088..36614 Replicon plasmid pIncFIB-1301491
Accession NZ_CP031569
Organism Enterobacter hormaechei strain 2013_1a

Toxin (Protein)


Gene name relE Uniprot ID A0A7R6HXL1
Locus tag AXA59_RS25385 Protein ID WP_015572079.1
Coordinates 36327..36614 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag AXA59_RS25380 Protein ID WP_000534858.1
Coordinates 36088..36327 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA59_RS25355 31161..32096 - 936 WP_004118100.1 GlxA family transcriptional regulator -
AXA59_RS25360 32107..33306 - 1200 WP_032670835.1 MFS transporter -
AXA59_RS25365 33349..34110 - 762 WP_004118132.1 SDR family NAD(P)-dependent oxidoreductase -
AXA59_RS25370 34140..34955 - 816 WP_032670836.1 SDR family oxidoreductase -
AXA59_RS25375 35419..35739 + 321 WP_004197483.1 hypothetical protein -
AXA59_RS25380 36088..36327 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
AXA59_RS25385 36327..36614 + 288 WP_015572079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXA59_RS25390 36686..36844 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
AXA59_RS25400 37712..38005 + 294 WP_032670838.1 hypothetical protein -
AXA59_RS25405 38022..38843 + 822 WP_015572081.1 DUF945 domain-containing protein -
AXA59_RS25410 38872..39411 - 540 WP_032664846.1 lytic transglycosylase domain-containing protein -
AXA59_RS25415 40010..40396 + 387 WP_015572083.1 conjugal transfer protein TraM -
AXA59_RS25420 40435..41076 - 642 WP_015572084.1 Arc family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..140243 140243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11209.09 Da        Isoelectric Point: 10.0714

>T109436 WP_015572079.1 NZ_CP031569:36327-36614 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T109436 NZ_CP031569:36327-36614 [Enterobacter hormaechei]
ATGGCATATTTTCTGGATTTTGACGAGCGTGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGCTAAA
AAATAAGTTGGCTGAAGTGCTTGAGTCACCCCGAATTGATGCGAACAAGCTTCGGGGTATGCATGACTGTTACAAAATTA
AGCTCCGGTCTTCAGGCTATCGTCTTGTATATCAGGTCATAGACGAGAAGGTTGTCGTCTTTGTGATTTCTGTCGGGAAA
AGAGAGCGCTCGGAAGTTTATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT109436 WP_000534858.1 NZ_CP031569:36088-36327 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT109436 NZ_CP031569:36088-36327 [Enterobacter hormaechei]
ATGGGTAGCATCAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCTGCGCTTGAAAAAATGGGTGTAACTCC
CTCTGAGGCACTTCGCCTCATGCTTGAATATATTGCTGACAATGAACGTTTGCCGTTCAAACAGACACTCCTGAGTGATG
AGGATGCTGAGCTCGTGGAGATCGTGAAAGAACGACTTCGCAATCCTAAGCCAGTACGTGTGACGCTGGATGAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References