Detailed information of TA system TA109434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4447790..4448529
• Replicon: chromosome
• Accession: NZ_CP031565
• Organism: Enterobacter hormaechei strain 2013_1a

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A0A801DRD7
• Locus tag: AXA59_RS21815
• Protein ID: WP_017693417.1
• Coordinates: 4448044..4448529 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A837FCR9
• Locus tag: AXA59_RS21810
• Protein ID: WP_003857131.1
• Coordinates: 4447790..4448056 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXA59_RS21790	4443272..4444258	+	987	WP_023296632.1	DUF979 domain-containing protein	-
AXA59_RS21795	4444268..4445263	+	996	WP_015570513.1	DUF2891 domain-containing protein	-
AXA59_RS21800	4445285..4446667	-	1383	WP_110870590.1	MFS transporter	-
AXA59_RS21805	4446797..4447726	+	930	WP_110870592.1	LysR family transcriptional regulator	-
AXA59_RS21810	4447790..4448056	+	267	WP_003857131.1	DUF1778 domain-containing protein	Antitoxin
AXA59_RS21815	4448044..4448529	+	486	WP_017693417.1	GNAT family N-acetyltransferase	Toxin
AXA59_RS21820	4448707..4449999	-	1293	WP_110870594.1	glycoside hydrolase	-
AXA59_RS21825	4450104..4450862	-	759	WP_047637345.1	DeoR/GlpR family DNA-binding transcription regulator	-
AXA59_RS21830	4450949..4451533	+	585	WP_017382349.1	GDP-mannose pyrophosphatase nudK	-
AXA59_RS21835	4451618..4452376	+	759	WP_063151482.1	trans-aconitate 2-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (58-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17570.26 Da
• Isoelectric Point: 9.9658

>T109434 WP_017693417.1 NZ_CP031565:4448044-4448529 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKTFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T109434 NZ_CP031565:4448044-4448529 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAACGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10090.50 Da
• Isoelectric Point: 4.3837

>AT109434 WP_003857131.1 NZ_CP031565:4447790-4448056 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT109434 NZ_CP031565:4447790-4448056 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FCR9