Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3044371..3045028 Replicon chromosome
Accession NZ_CP031565
Organism Enterobacter hormaechei strain 2013_1a

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag AXA59_RS15100 Protein ID WP_023295382.1
Coordinates 3044618..3045028 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AXA59_RS15095 Protein ID WP_003863437.1
Coordinates 3044371..3044637 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA59_RS15075 3039777..3041210 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
AXA59_RS15080 3041330..3042058 - 729 WP_039269836.1 MurR/RpiR family transcriptional regulator -
AXA59_RS15085 3042325..3042984 + 660 WP_003863433.1 hemolysin III family protein -
AXA59_RS15090 3043096..3044076 - 981 WP_039269839.1 tRNA-modifying protein YgfZ -
AXA59_RS15095 3044371..3044637 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AXA59_RS15100 3044618..3045028 + 411 WP_023295382.1 protein YgfX Toxin
AXA59_RS15105 3045030..3045551 - 522 WP_015571793.1 flavodoxin FldB -
AXA59_RS15110 3045653..3046549 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AXA59_RS15115 3046578..3047291 + 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AXA59_RS15120 3047297..3049030 + 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T109427 WP_023295382.1 NZ_CP031565:3044618-3045028 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T109427 NZ_CP031565:3044618-3045028 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGCGCGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT109427 WP_003863437.1 NZ_CP031565:3044371-3044637 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT109427 NZ_CP031565:3044371-3044637 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References