Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | KacT-ataR/DUF1778(antitoxin) |
| Location | 385632..386429 | Replicon | chromosome |
| Accession | NZ_CP031565 | ||
| Organism | Enterobacter hormaechei strain 2013_1a | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | - |
| Locus tag | AXA59_RS02220 | Protein ID | WP_110870847.1 |
| Coordinates | 385632..386153 (-) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A331QJY7 |
| Locus tag | AXA59_RS02225 | Protein ID | WP_015570876.1 |
| Coordinates | 386160..386429 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AXA59_RS02190 | 381230..381919 | + | 690 | WP_045349209.1 | pyrimidine utilization protein B | - |
| AXA59_RS02195 | 381931..382317 | + | 387 | WP_015570870.1 | pyrimidine utilization protein C | - |
| AXA59_RS02200 | 382325..383125 | + | 801 | WP_110870841.1 | pyrimidine utilization protein D | - |
| AXA59_RS02205 | 383135..383725 | + | 591 | WP_110870843.1 | malonic semialdehyde reductase | - |
| AXA59_RS02210 | 383738..384229 | + | 492 | WP_110870845.1 | pyrimidine utilization flavin reductase protein F | - |
| AXA59_RS02215 | 384251..385573 | + | 1323 | WP_047717623.1 | pyrimidine utilization transport protein G | - |
| AXA59_RS02220 | 385632..386153 | - | 522 | WP_110870847.1 | GNAT family N-acetyltransferase | Toxin |
| AXA59_RS02225 | 386160..386429 | - | 270 | WP_015570876.1 | DUF1778 domain-containing protein | Antitoxin |
| AXA59_RS02230 | 386503..387408 | - | 906 | WP_032653183.1 | DMT family transporter | - |
| AXA59_RS02235 | 387525..387695 | - | 171 | WP_001273664.1 | general stress protein | - |
| AXA59_RS02240 | 388087..388683 | + | 597 | WP_006809323.1 | NAD(P)H:quinone oxidoreductase | - |
| AXA59_RS02245 | 388702..388929 | + | 228 | WP_006809324.1 | YccJ family protein | - |
| AXA59_RS02250 | 388961..390202 | - | 1242 | WP_047729185.1 | bifunctional glucose-1-phosphatase/inositol phosphatase | - |
| AXA59_RS02255 | 390355..390519 | + | 165 | WP_017693668.1 | helix-turn-helix transcriptional regulator | - |
| AXA59_RS02260 | 390529..390888 | - | 360 | WP_017384779.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19463.27 Da Isoelectric Point: 7.4318
>T109423 WP_110870847.1 NZ_CP031565:c386153-385632 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKIQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKIQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
Download Length: 522 bp
>T109423 NZ_CP031565:c386153-385632 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGATTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGATTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10247.75 Da Isoelectric Point: 5.8836
>AT109423 WP_015570876.1 NZ_CP031565:c386429-386160 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME
Download Length: 270 bp
>AT109423 NZ_CP031565:c386429-386160 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|