Detailed information of TA system TA109418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2368927..2369837
• Replicon: chromosome
• Accession: NZ_CP031560
• Organism: Dickeya dianthicola strain ME23

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: DZA65_RS11180
• Protein ID: WP_024105930.1
• Coordinates: 2369367..2369837 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A3A4C852
• Locus tag: DZA65_RS11175
• Protein ID: WP_024105929.1
• Coordinates: 2368927..2369370 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZA65_RS11150	2363985..2364656	+	672	WP_024105924.1	dethiobiotin synthase	-
DZA65_RS11155	2364930..2365286	-	357	WP_024105925.1	DUF1283 family protein	-
DZA65_RS11160	2365492..2366241	-	750	WP_024105926.1	bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG	-
DZA65_RS11165	2366545..2367771	-	1227	WP_024105927.1	glycosyl transferase	-
DZA65_RS11170	2367790..2368617	-	828	WP_024105928.1	mannosyl-3-phosphoglycerate phosphatase-related protein	-
DZA65_RS11175	2368927..2369370	+	444	WP_024105929.1	DUF2384 domain-containing protein	Antitoxin
DZA65_RS11180	2369367..2369837	+	471	WP_024105930.1	RES family NAD+ phosphorylase	Toxin
DZA65_RS22885	2369843..2370130	+	288	WP_024105931.1	hypothetical protein	-
DZA65_RS11185	2370513..2371517	-	1005	WP_103415876.1	acyltransferase family protein	-
DZA65_RS11195	2372209..2373170	+	962	Protein_2139	dicarboxylate transporter/tellurite-resistance protein TehA	-
DZA65_RS11200	2373471..2374169	+	699	WP_081634336.1	Expansin-YoaJ	-
DZA65_RS11210	2374410..2374705	-	296	Protein_2141	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (16-147)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17578.95 Da
• Isoelectric Point: 4.7269

>T109418 WP_024105930.1 NZ_CP031560:2369367-2369837 [Dickeya dianthicola]
MILYRLTKTKYLSTVWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAHILDYYTLLRIDVPDDHIQSVNMN
DLPENWAEEDAPPELAAYGDAWCFTKSSIALRVPSTLSPVEFNYLLNPEHPDFSSIIQNADTIPFQFDSRLKPAIK

Nucleotide

• Length: 471 bp

>T109418 NZ_CP031560:2369367-2369837 [Dickeya dianthicola]
TTGATTCTCTACAGGCTGACCAAGACAAAATATCTTTCTACAGTCTGGACGGGATATGGGGCAAAAGAGGCAGGAGGTCG
CTGGAACAGTGTAGGTGTCTCGATGGTATATGTGTCTGAAACAGCATCGCTTACGATGCTTGAGACGCTTGTACATCTGC
ATGCTGCACATATTCTGGATTATTATACTCTGCTGCGTATTGATGTCCCTGATGACCATATTCAGAGCGTCAATATGAAC
GACTTGCCAGAAAATTGGGCTGAAGAAGACGCGCCGCCTGAGCTTGCTGCTTACGGTGATGCTTGGTGCTTTACCAAAAG
TTCGATAGCCTTGCGTGTCCCCAGCACTTTATCTCCCGTGGAATTTAACTACCTTTTAAACCCCGAGCACCCTGACTTCT
CCTCGATCATCCAGAACGCTGACACCATTCCGTTCCAGTTTGATAGCAGGCTGAAACCGGCGATTAAATAG

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16506.81 Da
• Isoelectric Point: 9.6195

>AT109418 WP_024105929.1 NZ_CP031560:2368927-2369370 [Dickeya dianthicola]
MKTFSLSTTQTRPPRLWQVAGLNNSDGVALLGQINEGLDGTVANVIIDWAKITQNDLRKMSGIPSTTFSRSRKARFTADQ
SERLVRIIRVIDRAVELFEGDKDEAQKWLNEPNRALSWKVPAELMASETGAYEVMKLITRLEHGAYS

Nucleotide

• Length: 444 bp

>AT109418 NZ_CP031560:2368927-2369370 [Dickeya dianthicola]
ATGAAAACATTTAGCTTATCCACGACACAGACCCGGCCGCCACGCTTGTGGCAGGTTGCGGGGTTAAACAATTCTGATGG
TGTAGCACTGCTGGGCCAGATTAACGAAGGCCTTGATGGCACAGTTGCAAACGTGATCATTGACTGGGCAAAGATCACGC
AGAACGACCTGCGCAAAATGTCCGGTATACCGTCCACGACATTCAGTCGTAGCCGGAAAGCCCGATTCACCGCCGACCAA
AGTGAGCGACTGGTGCGCATTATTCGCGTTATAGATCGGGCTGTAGAACTGTTCGAGGGTGATAAAGACGAGGCCCAGAA
ATGGTTGAATGAGCCAAACAGAGCACTGAGCTGGAAAGTGCCAGCGGAACTGATGGCCTCCGAAACCGGCGCTTACGAGG
TCATGAAATTGATTACACGCCTGGAGCATGGGGCATACTCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A3A4C852