Detailed information of TA system TA109406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): itaRT/DUF1778(antitoxin)
• Location: 1319344..1320172
• Replicon: chromosome
• Accession: NZ_CP031560
• Organism: Dickeya dianthicola strain ME23

Toxin (Protein)

• Gene name: itaT
• Uniprot ID: A0A3A4CQM7
• Locus tag: DZA65_RS06330
• Protein ID: WP_024105035.1
• Coordinates: 1319344..1319880 (-)
• Length: 179 a.a.

Antitoxin (Protein)

• Gene name: itaR
• Uniprot ID: A0A385XV02
• Locus tag: DZA65_RS06335
• Protein ID: WP_026594683.1
• Coordinates: 1319861..1320172 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZA65_RS06310	1314690..1315658	+	969	WP_024105031.1	o-succinylbenzoate synthase	-
DZA65_RS06315	1315646..1317016	+	1371	WP_024108474.1	o-succinylbenzoate--CoA ligase	-
DZA65_RS06320	1317223..1317768	+	546	WP_024105033.1	membrane protein	-
DZA65_RS06325	1317991..1319184	+	1194	WP_024105034.1	nicotinamide mononucleotide deamidase-related protein YfaY	-
DZA65_RS06330	1319344..1319880	-	537	WP_024105035.1	GNAT family N-acetyltransferase	Toxin
DZA65_RS06335	1319861..1320172	-	312	WP_026594683.1	DUF1778 domain-containing protein	Antitoxin
DZA65_RS06340	1320471..1320740	-	270	Protein_1200	IS4 family transposase	-
DZA65_RS06345	1320843..1321703	-	861	WP_024105037.1	co-chaperone YbbN	-
DZA65_RS06350	1321766..1322542	-	777	WP_024105038.1	SDR family oxidoreductase	-
DZA65_RS06355	1322606..1323247	-	642	WP_024108475.1	multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1	-
DZA65_RS06360	1323215..1323901	+	687	WP_024107942.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (66-154)

Antitoxin

• Vibrio phage ICP1, Orf50 (13-97)

Sequences

Toxin

Protein

• Length: 179 a.a.
• Molecular weight: 19327.27 Da
• Isoelectric Point: 6.7055

>T109406 WP_024105035.1 NZ_CP031560:c1319880-1319344 [Dickeya dianthicola]
MVDTQSESNGVVVYAYQADTTYPGSKSFDCGNTVINSFVRSSLKKSVRDGNCAAKVLVKDETKELLGFCTFAAYSLEKSK
LAGVVSGSLPHELGVVRLIMLGVATKEQNKGYGQELLLEFFKQVKTIHESLPVKGVYLDADPAAIDFYIRLGFVQLNEPP
NAFGAVPMFLAIQHILAA

Nucleotide

• Length: 537 bp

>T109406 NZ_CP031560:c1319880-1319344 [Dickeya dianthicola]
ATGGTAGATACTCAAAGTGAAAGTAATGGTGTAGTGGTATACGCGTATCAGGCAGATACCACATACCCTGGGAGTAAGAG
TTTCGATTGCGGAAATACCGTAATCAACTCTTTTGTGCGTAGCTCCCTCAAGAAAAGCGTCAGAGATGGGAATTGTGCAG
CTAAAGTATTGGTTAAAGATGAAACAAAAGAGCTGTTGGGTTTCTGTACTTTTGCTGCTTACTCTCTTGAAAAAAGTAAG
TTGGCGGGGGTGGTTTCAGGTTCATTGCCTCATGAATTAGGGGTTGTTCGGCTAATTATGCTGGGGGTAGCCACGAAAGA
ACAGAATAAAGGCTATGGACAAGAACTGCTTTTAGAATTCTTTAAACAGGTTAAAACCATCCACGAATCGCTACCTGTTA
AAGGCGTGTATTTGGATGCGGATCCGGCAGCAATTGACTTCTATATCCGGTTAGGTTTCGTTCAACTTAATGAACCACCG
AATGCTTTTGGTGCGGTGCCCATGTTTTTGGCCATTCAACATATCCTTGCTGCGTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11420.03 Da
• Isoelectric Point: 10.5508

>AT109406 WP_026594683.1 NZ_CP031560:c1320172-1319861 [Dickeya dianthicola]
MSNVSVFPNDIRVTKNARVELKTSPDLKDVLREAATAAGLDLSAFILNAALERAESVLDNQRRRQLSAASWQQLNQLLSE
PAAPTLALQALMQRKKQDGRYSK

Nucleotide

• Length: 312 bp

>AT109406 NZ_CP031560:c1320172-1319861 [Dickeya dianthicola]
ATGTCTAATGTATCAGTGTTTCCCAATGATATTCGCGTCACGAAGAACGCGCGGGTGGAGTTAAAAACTAGCCCTGACCT
TAAAGATGTGCTTCGTGAAGCAGCTACGGCTGCAGGTTTAGATTTGAGTGCGTTTATTCTTAATGCCGCCCTGGAGCGAG
CAGAAAGCGTCCTGGATAACCAGCGGCGCCGACAGCTTTCAGCAGCAAGCTGGCAACAATTAAACCAACTCTTGTCTGAA
CCTGCTGCACCGACGCTGGCTTTACAGGCGTTAATGCAGAGGAAGAAACAAGATGGTAGATACTCAAAGTGA

Structures

Toxin

• AlphaFold DB: A0A3A4CQM7

Antitoxin

• AlphaFold DB: A0A385XV02