Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 981395..981921 Replicon chromosome
Accession NZ_CP031560
Organism Dickeya dianthicola strain ME23

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3A4CNM8
Locus tag DZA65_RS04715 Protein ID WP_024104817.1
Coordinates 981395..981700 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3A4CA80
Locus tag DZA65_RS04720 Protein ID WP_024104818.1
Coordinates 981703..981921 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZA65_RS04690 976455..977474 + 1020 WP_024104816.1 NADP-dependent oxidoreductase -
DZA65_RS04695 977675..978679 + 1005 WP_099327157.1 IS110 family transposase -
DZA65_RS04700 978988..979191 + 204 Protein_886 transposase -
DZA65_RS04705 979181..979800 - 620 Protein_887 transposase -
DZA65_RS04710 980108..981111 - 1004 Protein_888 IS110 family transposase -
DZA65_RS04715 981395..981700 - 306 WP_024104817.1 type II toxin-antitoxin system toxin CcdB Toxin
DZA65_RS04720 981703..981921 - 219 WP_024104818.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DZA65_RS04725 981980..982306 - 327 Protein_891 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
DZA65_RS23020 982298..982426 - 129 Protein_892 DUF4102 domain-containing protein -
DZA65_RS04735 982865..983581 - 717 WP_103415838.1 M48 family metallopeptidase -
DZA65_RS04740 983581..986676 - 3096 WP_103415839.1 HsdR family type I site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11820.63 Da        Isoelectric Point: 4.6983

>T109403 WP_024104817.1 NZ_CP031560:c981700-981395 [Dickeya dianthicola]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKTLFPQIRIDGEDYRLMTTELSSVPVEVIGEEL
AELGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T109403 NZ_CP031560:c981700-981395 [Dickeya dianthicola]
ATGCAATTCATTGTTTACCAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCAAAGCGGCGTATGGTCATTCCGCTTATAGAATCGCATCACCTGTCTGAGAAGGTGAATAAAACGCTGTTCCCTCAGA
TCCGGATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTTCCCGTTGAAGTTATTGGTGAAGAGCTC
GCGGAGCTTGGCGACTATGCGGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8191.17 Da        Isoelectric Point: 8.6383

>AT109403 WP_024104818.1 NZ_CP031560:c981921-981703 [Dickeya dianthicola]
MKHRVSVTVDKDNYQILSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT109403 NZ_CP031560:c981921-981703 [Dickeya dianthicola]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAACTATCAGATTCTGAGTGCTGCCGGAGTCAATATTTCTGGTCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGCAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAAAATGGCTCGTTTGCTGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A4CNM8

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CA80

References