Detailed information of TA system TA109399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1058273..1058885
• Replicon: chromosome
• Accession: NZ_CP031556
• Organism: Streptococcus agalactiae strain Sag27

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: DY328_RS05700
• Protein ID: WP_000384859.1
• Coordinates: 1058273..1058608 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: DY328_RS05705
• Protein ID: WP_000259017.1
• Coordinates: 1058598..1058885 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DY328_RS05670	1053471..1054112	+	642	WP_000591145.1	hypothetical protein	-
DY328_RS05680	1054412..1055287	+	876	WP_000421237.1	hypothetical protein	-
DY328_RS05685	1055323..1055757	+	435	WP_001220482.1	hypothetical protein	-
DY328_RS05690	1056074..1057330	+	1257	WP_000122836.1	plasmid recombination protein	-
DY328_RS05695	1057498..1057968	+	471	WP_000130119.1	hypothetical protein	-
DY328_RS05700	1058273..1058608	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DY328_RS05705	1058598..1058885	-	288	WP_000259017.1	hypothetical protein	Antitoxin
DY328_RS05710	1059392..1059682	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
DY328_RS05715	1059784..1060191	+	408	WP_000749954.1	hypothetical protein	-
DY328_RS05720	1060191..1060751	+	561	WP_001865562.1	hypothetical protein	-
DY328_RS05725	1060724..1061404	+	681	WP_001865565.1	hypothetical protein	-
DY328_RS05730	1061389..1061775	+	387	WP_000259069.1	hypothetical protein	-
DY328_RS05735	1061809..1062090	+	282	WP_000052406.1	hypothetical protein	-
DY328_RS05755	1062933..1063793	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T109399 WP_000384859.1 NZ_CP031556:c1058608-1058273 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T109399 NZ_CP031556:c1058608-1058273 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT109399 WP_000259017.1 NZ_CP031556:c1058885-1058598 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT109399 NZ_CP031556:c1058885-1058598 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6