Detailed information of TA system TA109398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1040835..1041386
• Replicon: chromosome
• Accession: NZ_CP031556
• Organism: Streptococcus agalactiae strain Sag27

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7Z6WID7
• Locus tag: DY328_RS05590
• Protein ID: WP_000285204.1
• Coordinates: 1040835..1041113 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Z6WI90
• Locus tag: DY328_RS05595
• Protein ID: WP_000246822.1
• Coordinates: 1041114..1041386 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DY328_RS05555	1035912..1036298	-	387	WP_000058816.1	hypothetical protein	-
DY328_RS05560	1036276..1037508	-	1233	WP_000625216.1	replication initiation factor domain-containing protein	-
DY328_RS05565	1037720..1039378	-	1659	WP_001882899.1	cell division protein FtsK	-
DY328_RS05570	1039385..1039795	-	411	WP_000216328.1	DUF961 family protein	-
DY328_RS05575	1039818..1040132	-	315	WP_000406626.1	hypothetical protein	-
DY328_RS05580	1040246..1040473	-	228	WP_001105756.1	hypothetical protein	-
DY328_RS05585	1040470..1040706	-	237	WP_001000876.1	hypothetical protein	-
DY328_RS05590	1040835..1041113	-	279	WP_000285204.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DY328_RS05595	1041114..1041386	-	273	WP_000246822.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DY328_RS05600	1042067..1042429	+	363	WP_000483806.1	helix-turn-helix domain-containing protein	-
DY328_RS05605	1042436..1043287	+	852	WP_001189027.1	ImmA/IrrE family metallo-endopeptidase	-
DY328_RS05610	1043307..1043669	-	363	WP_000722890.1	hypothetical protein	-
DY328_RS05615	1043757..1045307	-	1551	WP_001145976.1	DNA cytosine methyltransferase	-
DY328_RS05620	1045501..1045962	+	462	WP_000443123.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1025335..1051634	26299

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-79)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10954.81 Da
• Isoelectric Point: 8.0384

>T109398 WP_000285204.1 NZ_CP031556:c1041113-1040835 [Streptococcus agalactiae]
MYQVKFTSTFKKSYKRIKKRGLEMTLLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Nucleotide

• Length: 279 bp

>T109398 NZ_CP031556:c1041113-1040835 [Streptococcus agalactiae]
ATGTATCAAGTCAAGTTCACCTCTACTTTTAAAAAGAGCTATAAAAGGATTAAAAAGCGAGGCTTAGAGATGACACTCTT
AGATGAAGTGATTGAAAAACTCCGTCTAGGTCAGACACTCGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGTCATATTAAACCAGATTGGCTCTTGATTTATCTGATTGAAGACGATATTTTGACTTTAACCTTA
GCCGACACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9904.41 Da
• Isoelectric Point: 6.2580

>AT109398 WP_000246822.1 NZ_CP031556:c1041386-1041114 [Streptococcus agalactiae]
MATVPTQIRIDETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDKTIASYDN
LADLKKALDA

Nucleotide

• Length: 273 bp

>AT109398 NZ_CP031556:c1041386-1041114 [Streptococcus agalactiae]
ATGGCAACTGTACCAACTCAAATTCGGATTGATGAAACTGTAAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGAAT
GGATATGTCTAGTGCGGTCAATATTTTTCTTCGTCAATGTCTATTGCGTGGTGGACTTCCTTTCACAGTTGAAGTTCCTA
ATTATAGTCAAAAAACCTTAGAAGCTCTGGCAGAAGCTAAACGAATCTCTCGTGATAAAACGATCGCTTCTTATGACAAT
CTAGCAGATTTAAAGAAGGCTCTGGACGCTTAG

Structures

Toxin

• AlphaFold DB: A0A7Z6WID7

Antitoxin

• AlphaFold DB: A0A7Z6WI90