109395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2186051..2186610 Replicon chromosome
Accession NZ_CP031555
Organism Thalassospira indica strain PB8BT (=MCCC 1A01103T=LMG 29620T)

Toxin (Protein)


Gene name parE Uniprot ID A0A199Y953
Locus tag DY252_RS10275 Protein ID WP_064790377.1
Coordinates 2186051..2186344 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A199Y8Q3
Locus tag DY252_RS10280 Protein ID WP_064790378.1
Coordinates 2186332..2186610 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DY252_RS10250 2181169..2181969 - 801 WP_064790373.1 ABC transporter ATP-binding protein -
DY252_RS10255 2181984..2182778 - 795 WP_064790374.1 ABC transporter permease -
DY252_RS10260 2182819..2183796 - 978 WP_064790375.1 ABC transporter substrate-binding protein -
DY252_RS10265 2183854..2184870 - 1017 WP_174713876.1 agmatinase -
DY252_RS10270 2185076..2186029 + 954 WP_064790376.1 LysR family transcriptional regulator -
DY252_RS10275 2186051..2186344 - 294 WP_064790377.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DY252_RS10280 2186332..2186610 - 279 WP_064790378.1 CopG family ribbon-helix-helix protein Antitoxin
DY252_RS10285 2186866..2187999 + 1134 WP_064790379.1 LysR family transcriptional regulator -
DY252_RS10290 2188244..2189719 + 1476 WP_082923600.1 pentapeptide repeat-containing protein -
DY252_RS10295 2189878..2190921 + 1044 WP_064790381.1 patatin-like phospholipase family protein -
DY252_RS10300 2190952..2191521 + 570 WP_064790382.1 sugar O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11032.60 Da        Isoelectric Point: 10.3952

>T109395 WP_064790377.1 NZ_CP031555:c2186344-2186051 [Thalassospira indica]
MPQVRFAPAAIRDLQRLRDFLRSKNPDAARRAGEAIRQGVKVLGAHPNLGRLVDDLPEAFREWLIEFGDSGYVVRYRIDA
DTVTILVIRHQREAGHS

Download         Length: 294 bp

>T109395 NZ_CP031555:c2186344-2186051 [Thalassospira indica]
ATGCCGCAAGTAAGATTTGCACCGGCAGCCATTCGGGATCTGCAACGGCTCCGTGACTTTCTGCGCTCAAAAAACCCTGA
TGCCGCGCGCCGTGCCGGAGAAGCCATCCGTCAAGGCGTGAAAGTGCTTGGCGCCCACCCGAACCTTGGCCGACTGGTCG
ATGACCTTCCTGAAGCGTTTCGGGAATGGCTTATCGAGTTCGGTGACAGCGGCTATGTCGTGCGATACCGGATAGACGCG
GATACGGTGACCATTCTGGTCATCCGGCATCAGCGCGAAGCAGGACATTCTTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10887.18 Da        Isoelectric Point: 5.7867

>AT109395 WP_064790378.1 NZ_CP031555:c2186610-2186332 [Thalassospira indica]
MVSATSIKLDDDMKGRVRNLAEARQRTSHWIMREAIAQYVEREEKREALKRETVQAWEEFQQTGRHATAEEVDRWLESWG
TDDELPAPKCRK

Download         Length: 279 bp

>AT109395 NZ_CP031555:c2186610-2186332 [Thalassospira indica]
ATGGTATCTGCAACGTCCATCAAGCTCGATGACGACATGAAAGGCCGCGTTCGGAATCTTGCCGAAGCCCGGCAACGTAC
ATCGCACTGGATCATGCGCGAAGCGATCGCGCAATATGTCGAACGCGAAGAGAAGCGCGAGGCGCTAAAGCGTGAAACGG
TGCAGGCGTGGGAAGAGTTCCAGCAAACAGGCCGTCACGCAACGGCTGAAGAGGTCGACCGCTGGCTGGAAAGCTGGGGA
ACGGACGATGAATTACCCGCACCCAAATGCCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A199Y953

Antitoxin

Source ID Structure
AlphaFold DB A0A199Y8Q3

References