Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3101040..3101808 Replicon chromosome
Accession NZ_CP031546
Organism Escherichia coli strain cq9

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag DS732_RS16005 Protein ID WP_000854814.1
Coordinates 3101434..3101808 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3W4SUB1
Locus tag DS732_RS16000 Protein ID WP_044863316.1
Coordinates 3101040..3101345 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DS732_RS15965 3097881..3098336 + 456 WP_000581504.1 hypothetical protein -
DS732_RS15970 3098415..3098648 + 234 WP_001119729.1 DUF905 family protein -
DS732_RS15980 3098748..3099566 + 819 WP_001234629.1 DUF945 domain-containing protein -
DS732_RS15985 3099648..3100127 + 480 WP_000860087.1 antirestriction protein -
DS732_RS15990 3100143..3100619 + 477 WP_001186726.1 RadC family protein -
DS732_RS15995 3100682..3100903 + 222 WP_000692323.1 DUF987 domain-containing protein -
DS732_RS16000 3101040..3101345 + 306 WP_044863316.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DS732_RS16005 3101434..3101808 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
DS732_RS16010 3101805..3101999 + 195 WP_000988600.1 hypothetical protein -
DS732_RS16015 3102012..3102125 + 114 WP_001161660.1 DUF957 domain-containing protein -
DS732_RS16020 3102414..3102542 - 129 Protein_2908 transposase domain-containing protein -
DS732_RS16025 3102614..3102796 + 183 WP_001016348.1 hypothetical protein -
DS732_RS16030 3102897..3103226 - 330 WP_000450409.1 DUF496 family protein -
DS732_RS16035 3103398..3104456 - 1059 WP_001200891.1 FUSC family protein -
DS732_RS16040 3104654..3105127 - 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
DS732_RS16045 3105246..3106412 - 1167 WP_001464461.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T109362 WP_000854814.1 NZ_CP031546:3101434-3101808 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T109362 NZ_CP031546:3101434-3101808 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11250.00 Da        Isoelectric Point: 7.2621

>AT109362 WP_044863316.1 NZ_CP031546:3101040-3101345 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKA
DTLSSCGYVYLAVYPTPEMKN

Download         Length: 306 bp

>AT109362 NZ_CP031546:3101040-3101345 [Escherichia coli]
CTGCCCTGTACCGTGACGCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGC
CGGTATCAGAGGCCTGTTCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAAC
TCATGCTCACCAGCGGTGAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCC
GATACCCTCAGCAGTTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A3W4SUB1

References