Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 877824..879546 Replicon chromosome
Accession NZ_CP031546
Organism Escherichia coli strain cq9

Toxin (Protein)


Gene name mosT Uniprot ID A0A229ALQ0
Locus tag DS732_RS04520 Protein ID WP_052921265.1
Coordinates 878608..879546 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A229AKX4
Locus tag DS732_RS04515 Protein ID WP_052921266.1
Coordinates 877824..878615 (+) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DS732_RS04485 873498..873779 + 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
DS732_RS04490 873776..874402 + 627 WP_000667170.1 hypothetical protein -
DS732_RS04495 874386..875282 + 897 WP_052921278.1 type-F conjugative transfer system secretin TraK -
DS732_RS04500 875285..876574 + 1290 WP_052921268.1 TraB/VirB10 family protein -
DS732_RS04505 876649..877221 + 573 WP_024008834.1 type IV conjugative transfer system lipoprotein TraV -
DS732_RS04510 877218..877604 + 387 WP_000180225.1 hypothetical protein -
DS732_RS04515 877824..878615 + 792 WP_052921266.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
DS732_RS04520 878608..879546 + 939 WP_052921265.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
DS732_RS04525 880053..880709 - 657 WP_052921264.1 hypothetical protein -
DS732_RS31475 880753..880899 - 147 WP_162869655.1 hypothetical protein -
DS732_RS04530 881141..881833 + 693 WP_024008832.1 DsbC family protein -
DS732_RS04535 881833..884232 + 2400 WP_052921263.1 type IV secretion system protein TraC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 823025..921399 98374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35487.78 Da        Isoelectric Point: 5.1093

>T109346 WP_052921265.1 NZ_CP031546:878608-879546 [Escherichia coli]
MDKGSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSLVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNIYKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T109346 NZ_CP031546:878608-879546 [Escherichia coli]
ATGGATAAAGGCAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCCACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGGTTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCCGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATCGTTGTATCAAGTCTGGTTGCGACAATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAGATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCAGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTCCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTAGTGGGCTTTTTAACCTA
TACACTAAGTCATCCTCGGCCTATTAATGAAGTTATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCTATGATGTTAACTTCGCTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTTAAAAGAGGGCAACCTGACTGGGCATTGTTTGATTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATTTACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30113.48 Da        Isoelectric Point: 9.5097

>AT109346 WP_052921266.1 NZ_CP031546:877824-878615 [Escherichia coli]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLELNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWINRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT109346 NZ_CP031546:877824-878615 [Escherichia coli]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGAGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAGAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAAGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTAGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCAAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAC
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGACGGGATTGGGAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGATCAATCGCATAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACACAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A229ALQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A229AKX4

References