Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2462465..2462970 Replicon chromosome
Accession NZ_CP031537
Organism Staphylococcus aureus strain WCH-SK2

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6E6D5
Locus tag LR49_RS12965 Protein ID WP_001103946.1
Coordinates 2462677..2462970 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag LR49_RS12960 Protein ID WP_001058492.1
Coordinates 2462465..2462674 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LR49_RS12925 2457982..2459202 - 1221 WP_000264182.1 site-specific integrase -
LR49_RS12930 2459290..2460018 - 729 WP_000733773.1 staphylococcal enterotoxin type K -
LR49_RS12935 2460042..2460770 - 729 WP_001033317.1 staphylococcal enterotoxin type Q -
LR49_RS12940 2460945..2461679 - 735 WP_000142630.1 helix-turn-helix domain-containing protein -
LR49_RS12945 2461829..2462041 + 213 WP_001063624.1 helix-turn-helix transcriptional regulator -
LR49_RS12950 2462042..2462314 + 273 WP_001138298.1 helix-turn-helix domain-containing protein -
LR49_RS12955 2462326..2462472 + 147 WP_000784885.1 hypothetical protein -
LR49_RS12960 2462465..2462674 + 210 WP_001058492.1 hypothetical protein Antitoxin
LR49_RS12965 2462677..2462970 + 294 WP_001103946.1 DUF1474 family protein Toxin
LR49_RS12970 2463058..2463927 + 870 WP_001002692.1 primase alpha helix C-terminal domain-containing protein -
LR49_RS12975 2463944..2465401 + 1458 WP_000432707.1 virulence-associated E family protein -
LR49_RS12980 2465703..2466065 + 363 WP_001039172.1 hypothetical protein -
LR49_RS12985 2466067..2466351 + 285 WP_000998180.1 hypothetical protein -
LR49_RS12990 2466348..2466989 + 642 WP_001019783.1 hypothetical protein -
LR49_RS12995 2467438..2467779 + 342 WP_001190616.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage erm(A) selk / selq 2451193..2470093 18900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11590.08 Da        Isoelectric Point: 4.9594

>T109342 WP_001103946.1 NZ_CP031537:2462677-2462970 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Download         Length: 294 bp

>T109342 NZ_CP031537:2462677-2462970 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGACCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT109342 WP_001058492.1 NZ_CP031537:2462465-2462674 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT109342 NZ_CP031537:2462465-2462674 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6E6D5

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References