Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2438661..2439138 Replicon chromosome
Accession NZ_CP031537
Organism Staphylococcus aureus strain WCH-SK2

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag LR49_RS12780 Protein ID WP_000052078.1
Coordinates 2438661..2438849 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LR49_RS12785 Protein ID WP_001059690.1
Coordinates 2438878..2439138 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LR49_RS12750 2434702..2435172 + 471 WP_000824472.1 hypothetical protein -
LR49_RS12755 2435513..2436199 + 687 WP_001548082.1 thermonuclease family protein -
LR49_RS12760 2436556..2436756 + 201 WP_001059082.1 cold-shock protein -
LR49_RS12765 2437252..2437470 - 219 WP_000005877.1 hypothetical protein -
LR49_RS12770 2437532..2437816 - 285 WP_001004395.1 hypothetical protein -
LR49_RS12775 2437904..2438473 - 570 WP_001106654.1 hypothetical protein -
LR49_RS12780 2438661..2438849 - 189 WP_000052078.1 hypothetical protein Toxin
LR49_RS12785 2438878..2439138 - 261 WP_001059690.1 hypothetical protein Antitoxin
LR49_RS12790 2439479..2439682 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LR49_RS12795 2439679..2439915 - 237 WP_000368687.1 hypothetical protein -
LR49_RS12800 2440140..2440721 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
LR49_RS12805 2440794..2441411 - 618 WP_000255564.1 LysE/ArgO family amino acid transporter -
LR49_RS12810 2441566..2442060 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
LR49_RS12815 2442459..2442881 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
LR49_RS12820 2443029..2443745 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T109341 WP_000052078.1 NZ_CP031537:c2438849-2438661 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T109341 NZ_CP031537:c2438849-2438661 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT109341 WP_001059690.1 NZ_CP031537:c2439138-2438878 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT109341 NZ_CP031537:c2439138-2438878 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References