Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-ParD
Location 2601093..2602036 Replicon chromosome
Accession NZ_CP031516
Organism [Mycobacterium] chelonae subsp. gwanakae strain MOTT36W

Toxin (Protein)


Gene name zeta Uniprot ID A0A1S1LXZ5
Locus tag DYE20_RS12850 Protein ID WP_070917639.1
Coordinates 2601449..2602036 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID A0A809GVT6
Locus tag DYE20_RS12845 Protein ID WP_064408866.1
Coordinates 2601093..2601452 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYE20_RS12830 2597369..2599309 - 1941 WP_206193577.1 site-specific DNA-methyltransferase -
DYE20_RS12840 2599833..2600142 - 310 Protein_2508 hypothetical protein -
DYE20_RS12845 2601093..2601452 + 360 WP_064408866.1 hypothetical protein Antitoxin
DYE20_RS12850 2601449..2602036 + 588 WP_070917639.1 AAA family ATPase Toxin
DYE20_RS12855 2602211..2602543 + 333 WP_064408868.1 hypothetical protein -
DYE20_RS12865 2602840..2603187 + 348 WP_123771734.1 hypothetical protein -
DYE20_RS12870 2603887..2606112 + 2226 WP_070941014.1 S9 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-61)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21640.78 Da        Isoelectric Point: 8.5326

>T109322 WP_070917639.1 NZ_CP031516:2601449-2602036 [[Mycobacterium] chelonae subsp. gwanakae]
VKRLDLIVGPNGSGKTTFVAKFLAPLLHESVFVNADEIAKQRWPDEDPAPRAYEAARIAEQTRQALISQGRPFIAETVFS
HPSKLDLIRSAQAADYTVRLLVLLVPEELTVQRVAARVEAGGHSVPIEKIRARYERLWPLVVDAIALADSSVVFDNSSEP
GPRVVARMTRGQVVGTLTWPQWTPAPLWQRWTDSA

Download         Length: 588 bp

>T109322 NZ_CP031516:2601449-2602036 [[Mycobacterium] chelonae subsp. gwanakae]
GTGAAACGGCTCGATCTGATCGTCGGTCCCAATGGCTCAGGCAAGACAACCTTTGTCGCCAAGTTTCTCGCACCGCTGCT
GCATGAATCGGTGTTCGTCAACGCCGACGAGATCGCCAAGCAGCGCTGGCCCGACGAGGACCCTGCCCCGCGGGCATACG
AGGCTGCGCGCATCGCCGAGCAGACACGGCAAGCGTTGATCAGCCAGGGGCGCCCGTTCATCGCCGAGACAGTGTTCTCA
CATCCCTCAAAGCTGGACCTGATTCGATCAGCACAGGCCGCGGACTACACCGTCCGCCTACTGGTGCTTCTGGTGCCTGA
GGAGCTGACAGTGCAGCGTGTAGCGGCCCGGGTAGAAGCCGGCGGTCACAGTGTTCCGATCGAGAAGATCCGTGCGCGCT
ATGAGCGCTTATGGCCACTTGTTGTGGATGCGATCGCCCTGGCCGATTCGAGCGTTGTCTTCGACAACAGCTCTGAGCCA
GGGCCGCGTGTTGTGGCCCGGATGACGCGTGGCCAGGTCGTAGGAACGCTGACCTGGCCACAGTGGACACCCGCTCCTTT
GTGGCAGCGGTGGACAGACAGCGCGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13117.66 Da        Isoelectric Point: 4.7938

>AT109322 WP_064408866.1 NZ_CP031516:2601093-2601452 [[Mycobacterium] chelonae subsp. gwanakae]
MAAPVDRPTRVASDLLDSAAAEGARQSRSAKQQLDHWARLGREVSSQDNVSRRRVEAALSGQLSMRELTPEEGVVFNAEI
EVELERRIAATHLQDELRAEGMRVVVLNDAGEIVQYPPA

Download         Length: 360 bp

>AT109322 NZ_CP031516:2601093-2601452 [[Mycobacterium] chelonae subsp. gwanakae]
ATGGCGGCTCCGGTAGATCGCCCGACGCGCGTGGCGTCGGATCTTTTGGACAGCGCTGCGGCAGAAGGTGCGCGGCAGAG
TCGCTCGGCTAAGCAGCAGCTCGACCACTGGGCGCGGCTGGGTCGCGAAGTGAGTAGCCAGGACAACGTCTCGCGGCGGC
GGGTAGAGGCCGCGCTGTCCGGCCAGCTGAGCATGCGTGAGCTCACCCCGGAAGAGGGCGTGGTTTTCAACGCCGAAATC
GAGGTCGAGCTGGAGCGGCGGATCGCCGCAACGCACCTGCAAGATGAGCTGAGGGCCGAGGGTATGCGAGTCGTGGTTCT
CAATGACGCCGGCGAGATTGTGCAGTACCCACCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1LXZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A809GVT6

References