Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1137962..1138587 Replicon chromosome
Accession NZ_CP031515
Organism Dickeya zeae strain EC2

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag DWV07_RS05190 Protein ID WP_009114000.1
Coordinates 1137962..1138165 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2BUK3
Locus tag DWV07_RS05195 Protein ID WP_012883774.1
Coordinates 1138219..1138587 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWV07_RS05160 1133566..1133904 + 339 WP_002208627.1 P-II family nitrogen regulator -
DWV07_RS05165 1133948..1135240 + 1293 WP_019844639.1 ammonium transporter AmtB -
DWV07_RS05170 1135363..1136226 - 864 WP_019844638.1 acyl-CoA thioesterase II -
DWV07_RS05175 1136444..1137025 + 582 WP_168365137.1 YbaY family lipoprotein -
DWV07_RS05180 1137066..1137392 - 327 WP_168365138.1 MGMT family protein -
DWV07_RS05190 1137962..1138165 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
DWV07_RS05195 1138219..1138587 - 369 WP_012883774.1 Hha toxicity modulator TomB Antitoxin
DWV07_RS05200 1139097..1139240 - 144 WP_012770724.1 type B 50S ribosomal protein L36 -
DWV07_RS05205 1139256..1139507 - 252 WP_029456417.1 type B 50S ribosomal protein L31 -
DWV07_RS05210 1139681..1142827 - 3147 WP_168365139.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T109310 WP_009114000.1 NZ_CP031515:c1138165-1137962 [Dickeya zeae]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T109310 NZ_CP031515:c1138165-1137962 [Dickeya zeae]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGACGAACTTGAAATGTTCTATTCAGCTGCCGACCATCGTCTGGCTGAGCTAACGATGAATAAAC
TTTACGACAAAGTGCCAACTGCCGTATGGAAATACGTTCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14186.04 Da        Isoelectric Point: 5.1811

>AT109310 WP_012883774.1 NZ_CP031515:c1138587-1138219 [Dickeya zeae]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp

>AT109310 NZ_CP031515:c1138587-1138219 [Dickeya zeae]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
AACATTAGGCGACAGCAGTCGTGGATGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATATCCGCATGAAGCGGCGCTGTGTGAGCGGGTTGAAAAATACCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAATGATTCAGAGTTGCAGAAATGGAAAAAATCCAAGTCGCAATT
ATTCAGAATGTTCTCAGAAAAGAGCGTCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QCC2

References