Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4243363..4243965 Replicon chromosome
Accession NZ_CP031514
Organism Chromobacterium sp. Rain0013

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J6MTI0
Locus tag DXT74_RS19260 Protein ID WP_043634155.1
Coordinates 4243783..4243965 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J6JZA0
Locus tag DXT74_RS19255 Protein ID WP_043634152.1
Coordinates 4243363..4243773 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXT74_RS19240 4239808..4240689 - 882 WP_081862573.1 GlxA family transcriptional regulator -
DXT74_RS19245 4240926..4242071 + 1146 WP_052370372.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DXT74_RS19250 4242087..4243022 + 936 WP_194426785.1 PDR/VanB family oxidoreductase -
DXT74_RS19255 4243363..4243773 - 411 WP_043634152.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DXT74_RS19260 4243783..4243965 - 183 WP_043634155.1 type II toxin-antitoxin system HicA family toxin Toxin
DXT74_RS19265 4244249..4245661 - 1413 WP_081556622.1 sigma 54-interacting transcriptional regulator -
DXT74_RS19270 4246029..4246820 + 792 WP_194426786.1 ATP-binding cassette domain-containing protein -
DXT74_RS19275 4246840..4247613 + 774 WP_081556620.1 transporter substrate-binding domain-containing protein -
DXT74_RS19280 4247654..4248367 + 714 WP_052370374.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6578.73 Da        Isoelectric Point: 10.7364

>T109307 WP_043634155.1 NZ_CP031514:c4243965-4243783 [Chromobacterium sp. Rain0013]
VTSKEVISMIEADGWYLVAAKGSHQQFKHPIKTGRVTVPHPKKDIPIGTLNSIKKQAGLK

Download         Length: 183 bp

>T109307 NZ_CP031514:c4243965-4243783 [Chromobacterium sp. Rain0013]
GTGACCAGCAAAGAAGTCATCAGCATGATAGAGGCCGACGGCTGGTATCTGGTTGCCGCCAAGGGAAGCCATCAACAGTT
CAAACACCCGATCAAGACCGGCCGGGTGACGGTGCCTCACCCCAAGAAGGACATACCGATAGGCACGCTGAACAGCATCA
AGAAACAAGCGGGTCTCAAGTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14881.87 Da        Isoelectric Point: 4.6312

>AT109307 WP_043634152.1 NZ_CP031514:c4243773-4243363 [Chromobacterium sp. Rain0013]
MYYPIAVEPGDDQHAYGVIVPDLPGCFSAGDTLDEAIRNAREAIELHLEGLVEDLDVIPLASSAQAHVGKSEFAGHIWAL
VDVDITRYLGKATKINVTLPANLLHRIDEYVASHPEYDSRSGFLAKTALEKLLCRP

Download         Length: 411 bp

>AT109307 NZ_CP031514:c4243773-4243363 [Chromobacterium sp. Rain0013]
ATGTACTACCCGATTGCAGTTGAACCCGGTGATGACCAACATGCCTATGGCGTCATCGTGCCGGATCTACCCGGCTGCTT
TTCCGCCGGGGACACTCTGGATGAGGCCATCCGTAACGCCCGCGAAGCCATCGAACTGCATCTGGAAGGGCTGGTGGAAG
ACCTGGACGTTATCCCTCTGGCCAGCAGCGCGCAGGCTCATGTCGGTAAATCCGAGTTTGCCGGCCATATCTGGGCGCTG
GTGGATGTGGACATCACTCGCTATCTGGGTAAAGCGACCAAGATCAATGTCACGTTGCCGGCCAACCTTCTGCACCGTAT
CGATGAATATGTCGCTTCCCACCCGGAATATGATAGCCGCAGCGGTTTCCTGGCCAAGACCGCGCTAGAAAAGCTATTGT
GTCGGCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J6MTI0

Antitoxin

Source ID Structure
AlphaFold DB A0A0J6JZA0

References