Detailed information of TA system TA109295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1864577..1865194
• Replicon: chromosome
• Accession: NZ_CP031507
• Organism: Dickeya fangzhongdai strain QZH3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2K8QKH7
• Locus tag: DYD83_RS08385
• Protein ID: WP_071842437.1
• Coordinates: 1864991..1865194 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DYD83_RS08380
• Protein ID: WP_100849304.1
• Coordinates: 1864577..1864987 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYD83_RS08355	1860052..1860969	+	918	WP_100849301.1	iron-siderophore ABC transporter substrate-binding protein	-
DYD83_RS08360	1860999..1861988	+	990	WP_167389568.1	iron ABC transporter permease	-
DYD83_RS08365	1861999..1863030	+	1032	WP_039695444.1	iron ABC transporter permease	-
DYD83_RS08370	1863042..1863851	+	810	WP_049854931.1	ABC transporter ATP-binding protein	-
DYD83_RS08375	1863884..1864501	+	618	WP_100849303.1	RraA family protein	-
DYD83_RS08380	1864577..1864987	-	411	WP_100849304.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DYD83_RS08385	1864991..1865194	-	204	WP_071842437.1	type II toxin-antitoxin system HicA family toxin	Toxin
DYD83_RS08390	1865515..1865874	+	360	WP_100849305.1	hypothetical protein	-
DYD83_RS08395	1866179..1867234	-	1056	WP_100849306.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7347.47 Da
• Isoelectric Point: 11.0566

>T109295 WP_071842437.1 NZ_CP031507:c1865194-1864991 [Dickeya fangzhongdai]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGISSSLTQRG

Nucleotide

• Length: 204 bp

>T109295 NZ_CP031507:c1865194-1864991 [Dickeya fangzhongdai]
ATGGATAGCAGGACGTTGATAGCAGAAATCAAGGCCGATGGATGGGAGCTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCAGGATTAGTGACCATCCCACACCCTAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GAAAACAAGCGGGGATATCATCCTCACTGACTCAAAGAGGCTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14571.59 Da
• Isoelectric Point: 4.3494

>AT109295 WP_100849304.1 NZ_CP031507:c1864987-1864577 [Dickeya fangzhongdai]
MFYPIAIETGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKEAITGHIELLIEMGQDIPAVSSVGVLAKTPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Nucleotide

• Length: 411 bp

>AT109295 NZ_CP031507:c1864987-1864577 [Dickeya fangzhongdai]
ATGTTTTATCCAATTGCCATTGAAACAGGCGACGATACTCATGCATACGGCGTGACAGTGCCCGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACACTTGATGAGGCTATCGCCAATGCTAAAGAAGCGATCACCGGCCACATAGAGCTGCTGATCGAGA
TGGGCCAGGATATTCCCGCCGTGTCATCCGTAGGTGTGCTGGCGAAAACACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACTCGGCTGATGGGAGGGGCGGAAAAAATCAACGTCACACTGCCGAAGTCGCTGATTGACCGTAT
AGACCGCTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGATTTCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Structures

Toxin

• AlphaFold DB: A0A2K8QKH7