Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1315748..1316373 Replicon chromosome
Accession NZ_CP031507
Organism Dickeya fangzhongdai strain QZH3

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag DYD83_RS06055 Protein ID WP_009114000.1
Coordinates 1315748..1315951 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8QJA5
Locus tag DYD83_RS06060 Protein ID WP_042859087.1
Coordinates 1316005..1316373 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYD83_RS06025 1311387..1311725 + 339 WP_002208627.1 P-II family nitrogen regulator -
DYD83_RS06030 1311768..1313060 + 1293 WP_038661206.1 ammonium transporter AmtB -
DYD83_RS06035 1313153..1314016 - 864 WP_100849114.1 acyl-CoA thioesterase II -
DYD83_RS06040 1314269..1314829 + 561 WP_049854165.1 YbaY family lipoprotein -
DYD83_RS06045 1314858..1315187 - 330 WP_100849115.1 MGMT family protein -
DYD83_RS06055 1315748..1315951 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
DYD83_RS06060 1316005..1316373 - 369 WP_042859087.1 Hha toxicity modulator TomB Antitoxin
DYD83_RS06065 1316881..1317024 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
DYD83_RS06070 1317040..1317291 - 252 WP_038661187.1 type B 50S ribosomal protein L31 -
DYD83_RS06075 1317462..1320608 - 3147 WP_038918200.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T109293 WP_009114000.1 NZ_CP031507:c1315951-1315748 [Dickeya fangzhongdai]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T109293 NZ_CP031507:c1315951-1315748 [Dickeya fangzhongdai]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCAACTGCTGTGTGGAAATACGTTCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14200.07 Da        Isoelectric Point: 5.1811

>AT109293 WP_042859087.1 NZ_CP031507:c1316373-1316005 [Dickeya fangzhongdai]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT109293 NZ_CP031507:c1316373-1316005 [Dickeya fangzhongdai]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATAAATGACTCCGAGTTGCAGAAATGGAAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QJA5

References