Detailed information of TA system TA109289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 470651..471393
• Replicon: chromosome
• Accession: NZ_CP031507
• Organism: Dickeya fangzhongdai strain QZH3

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: C6C3X4
• Locus tag: DYD83_RS02210
• Protein ID: WP_015855199.1
• Coordinates: 470651..471130 (-)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A3N0G0N1
• Locus tag: DYD83_RS02215
• Protein ID: WP_019843650.1
• Coordinates: 471121..471393 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYD83_RS02180	466498..466698	+	201	WP_188726100.1	AlpA family transcriptional regulator	-
DYD83_RS02185	466695..467234	+	540	WP_100848772.1	ash family protein	-
DYD83_RS02190	467227..469269	+	2043	WP_100848773.1	AAA family ATPase	-
DYD83_RS02195	469492..469758	-	267	WP_013316114.1	helix-turn-helix domain-containing protein	-
DYD83_RS02200	469864..470076	+	213	Protein_418	transcriptional regulator	-
DYD83_RS02205	470221..470622	-	402	WP_100848774.1	hypothetical protein	-
DYD83_RS02210	470651..471130	-	480	WP_015855199.1	GNAT family N-acetyltransferase	Toxin
DYD83_RS02215	471121..471393	-	273	WP_019843650.1	DUF1778 domain-containing protein	Antitoxin
DYD83_RS02220	471659..472777	+	1119	Protein_422	IS3 family transposase	-
DYD83_RS02225	473040..473762	-	723	WP_100848775.1	methyltransferase domain-containing protein	-
DYD83_RS02230	473770..474027	-	258	WP_049855262.1	YjhX family toxin	-
DYD83_RS02235	474480..474818	-	339	WP_100848776.1	hypothetical protein	-
DYD83_RS02240	475206..475904	-	699	WP_145958393.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	460705..480572	19867

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (28-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (10-85)

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17538.30 Da
• Isoelectric Point: 9.5367

>T109289 WP_015855199.1 NZ_CP031507:c471130-470651 [Dickeya fangzhongdai]
VGITAPELLLPQHAVVDFHCSEPSLNEWLKRKALKNQTLGASRTFVVCEAGTQRVVGFYALASGSIQRQVAPGAFRRNMP
DPIPVLVLGRLAVDERYQRMGIGAGLLKDAVLRSRNVAQQVGNKALLVHALSDEAKAFYQYWGFVASEIQEHTLLLSLW

Nucleotide

• Length: 480 bp

>T109289 NZ_CP031507:c471130-470651 [Dickeya fangzhongdai]
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCGGTTGTGGATTTTCATTGTTCAGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAGGCGTTAAAAAATCAGACACTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGTACACAGC
GTGTGGTGGGGTTCTATGCCCTCGCGTCGGGTAGCATCCAGCGTCAGGTTGCGCCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTACTTGGCCGATTAGCCGTTGATGAACGTTATCAACGCATGGGGATCGGTGCCGGGCTCCT
GAAAGATGCGGTACTCCGCTCCCGCAATGTAGCGCAGCAGGTAGGCAACAAAGCGTTATTGGTACATGCGTTATCTGATG
AGGCAAAAGCGTTCTACCAATACTGGGGTTTTGTCGCGTCAGAAATACAGGAACACACCTTATTATTATCGTTATGGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10388.86 Da
• Isoelectric Point: 4.6702

>AT109289 WP_019843650.1 NZ_CP031507:c471393-471121 [Dickeya fangzhongdai]
MRTETKEMPINIRAKASQRELIDVAAKLLSKSRTEFILDAACREAEDVLLDQRLFLVNDEQYDAFIQVLESPVTDNPRVN
ALLNRKSPWE

Nucleotide

• Length: 273 bp

>AT109289 NZ_CP031507:c471393-471121 [Dickeya fangzhongdai]
ATGCGAACAGAGACAAAAGAAATGCCGATTAATATTCGTGCTAAAGCATCACAGCGGGAGCTGATTGATGTCGCTGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAGGATGTGTTGTTGGATCAACGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGTTGGAATCACCTGTCACAGATAATCCGCGTGTGAAT
GCATTACTGAACAGGAAATCTCCGTGGGAATAA

Structures

Toxin

• AlphaFold DB: A0A2K8QHE3

Antitoxin

• AlphaFold DB: A0A3N0G0N1