109287

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5021009..5022597 Replicon chromosome
Accession NZ_CP031505
Organism Dickeya fangzhongdai strain LN1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag DYD82_RS22200 Protein ID WP_100850374.1
Coordinates 5021278..5022597 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2K8QTG6
Locus tag DYD82_RS22195 Protein ID WP_038669098.1
Coordinates 5021009..5021278 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYD82_RS22170 5016331..5016942 - 612 WP_100850371.1 NAD(P)-dependent oxidoreductase -
DYD82_RS22175 5017084..5017464 + 381 WP_100850372.1 helix-turn-helix transcriptional regulator -
DYD82_RS22180 5017565..5018650 - 1086 WP_038920707.1 4-hydroxyphenylpyruvate dioxygenase -
DYD82_RS22185 5018966..5019739 + 774 WP_100850373.1 MBL fold metallo-hydrolase -
DYD82_RS22190 5019789..5020739 + 951 WP_100850517.1 helix-turn-helix domain-containing protein -
DYD82_RS22195 5021009..5021278 + 270 WP_038669098.1 helix-turn-helix domain-containing protein Antitoxin
DYD82_RS22200 5021278..5022597 + 1320 WP_100850374.1 type II toxin-antitoxin system HipA family toxin Toxin
DYD82_RS22205 5022632..5023996 - 1365 WP_100850375.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
DYD82_RS22210 5024112..5025743 - 1632 WP_100850376.1 membrane protein insertase YidC -
DYD82_RS22215 5025746..5026003 - 258 WP_013320102.1 membrane protein insertion efficiency factor YidD -
DYD82_RS22220 5025967..5026326 - 360 WP_013320101.1 ribonuclease P protein component -
DYD82_RS22225 5026345..5026485 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49234.37 Da        Isoelectric Point: 6.5751

>T109287 WP_100850374.1 NZ_CP031505:5021278-5022597 [Dickeya fangzhongdai]
MAALDVYMNGYRVGTLTKTGSGAHHFSYDENWLVLPGSRPISLSMPLRHQPYQGNEVYNFFDNLLPDNPDIRRRIVARHN
ADSTQPFDLLAKVGQDSVGALQLVPQGTPVGDIKQIEYKTLSEQQLENILAGYLADAPLGMIDAEDDFRISIAGAQEKTA
LLYLGDHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCMLVAKAFGLQVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSYLLGAVDPEKDRYSFMKTQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAQAVGFARESMESILTEFAQSM
DAVVVNVRNQLPADFPAPIRDAILEGMQARARRLMTGWE

Download         Length: 1320 bp

>T109287 NZ_CP031505:5021278-5022597 [Dickeya fangzhongdai]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGAGTGGGGACGTTGACCAAAACGGGTAGCGGCGCTCATCATTTTTC
CTATGATGAGAACTGGCTTGTGTTGCCGGGGAGCCGCCCCATCTCGCTCTCGATGCCGCTACGCCATCAGCCCTATCAAG
GTAATGAAGTTTATAATTTCTTCGACAATTTATTGCCGGATAACCCGGATATCAGAAGACGGATTGTCGCCAGACATAAC
GCAGATTCTACCCAACCGTTTGACCTGCTGGCTAAAGTGGGGCAGGACAGTGTCGGGGCGTTGCAATTGGTGCCGCAGGG
TACACCTGTTGGCGATATAAAACAGATCGAATACAAAACTTTATCCGAACAACAGCTTGAAAACATACTGGCGGGATACC
TGGCCGATGCGCCACTGGGGATGATTGATGCAGAAGATGATTTTCGTATCTCTATTGCTGGTGCACAGGAAAAGACGGCG
CTGCTCTATCTGGGGGATCACTGGTGTTTGCCCTTCAATACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCATTCTTACTCAATTGATATGTCTGACAGCGTTGAGAATGAGTATCTGTGCATGCTCGTGGCCAAGGCGT
TTGGGCTGCAGGTACCGCACTGTTTTATGATCACAGCAGGCAAGATAAAAGCGCTGGCGGTAGAACGTTTTGATCGTAAA
TACGCTTCGGATGGTCGTTGGATTATGCGGTTGCCGCAGGAGGATTTTTGCCAGGTATTAAACGTTCCTTCCGCACGGAA
ATACGAAAATCACGGTGGGCCGGGTATTTCCGCCATTATGTCGTATCTATTGGGTGCGGTTGATCCAGAAAAGGATCGTT
ATAGCTTCATGAAGACTCAGGTGCTGTTTTGGCTATTAGCCGCAACAGATGGGCATGCGAAAAATTTTTCCCTGTTTATT
GAATCTGAGGGACGATATCGTCTCACGCCTTTCTATGACATTCTCTCGATGTACCCGGCGATGGGCGGGCGGGGAATTGA
CCGTAGAGAGGCCAAACTGGCGATGGGATTGACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTCCCACGCC
ACTTTTTCCAAACGGCGCAGGCAGTTGGATTTGCCAGAGAATCGATGGAGAGTATTCTGACGGAGTTTGCGCAATCGATG
GATGCTGTTGTGGTGAACGTCAGAAATCAGCTGCCTGCGGATTTTCCTGCACCTATTCGTGATGCGATTCTCGAAGGTAT
GCAGGCCAGGGCAAGGCGATTAATGACCGGGTGGGAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9915.17 Da        Isoelectric Point: 10.0982

>AT109287 WP_038669098.1 NZ_CP031505:5021009-5021278 [Dickeya fangzhongdai]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNANAANNEASA
ATSSWKEEW

Download         Length: 270 bp

>AT109287 NZ_CP031505:5021009-5021278 [Dickeya fangzhongdai]
ATGAAGGTCACCAACAGCAAACAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGAAAAGT
AGCCAGTAAAGTGGGTATTCGCCAGGACACGGTATCCAGCTTCGAACAACACCCTGATTCCACCAAGCTGGAAACATTCT
TTAAAATCCTGTCGGCATTGAATTTAGAACTTACGATTACTCCCAGAAACGCAAATGCCGCCAATAACGAGGCTTCTGCT
GCAACATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QTG6

References